Acambis PLC Announces Board Change

Cambridge, UK and Cambridge, Massachusetts – 12 April 2006 – Acambis plc (“Acambis’) (LSE: ACM, NASDAQ: ACAM) announces that, on 11 April 2006, Michael Lytton resigned his position as a Non-executive Director of Acambis. Michael has been a Non-executive Director since March 2001.

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