Annovis Bio, Inc. today announced that patient recruitment for the Company’s Phase 2/3 study of buntanetap for the treatment of moderate Alzheimer’s disease (AD) remains consistent with its planned development program.
Phase 2/3 AD Study continues to make steady progress in patient recruitment Company to hold R&D webcast on Thursday, April 20th to review ongoing clinical programs in Alzheimer’s disease and Parkinson’s disease BERWYN, Pa., April 19, 2023 /PRNewswire/ -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a clinical-stage drug platform company addressing neurodegenerative diseases, today announced that patient recruitment for the Company’s Phase 2/3 study of buntanetap for the treatment of moderate Alzheimer’s disease (AD) remains consistent with its planned development program. To date, a total of 27 sites have now been activated and 38 patients have been screened in the Phase 2/3 study. In addition, 13 patients have been randomized to receive either one of three doses of buntanetap or placebo. Annovis will hold an R&D webcast on Thursday, April 20, 2023 at 4 PM to review its late-stage clinical programs in AD and Parkinson’s disease (PD). Details on the webcast are provide below: Webcast details: Date: April 20, 2023, 4PM Maria L. Maccecchini, Ph.D., Founder, President, and CEO of Annovis, commented: “We are very pleased to announce the ramp up of our Phase 2/3 study of buntanetap for the treatment of AD. AD is associated with chronic, low-level neuro-inflammation, which is likely due to the overexpression of neurotoxic proteins such as amyloid beta, tau, αSynuclein, and TDP43. By targeting the complex of the iron response element 1 (IRE1) with the mRNAs coding for these neurotoxic proteins, buntanetap blocks their translation and helps reduce the pro-inflammatory conditions seen in AD. In our upcoming R&D webcast, we look forward to discussing our Phase 2/3 trial as well as an overview of the planned development program for AD and PD.” The Phase 2/3 study is a randomized, double-blind, placebo-controlled trial investigating the efficacy, safety, and tolerability of buntanetap in moderate AD patients. The trial is expected to enroll a total of 320 AD patients into three active arms to be treated with 7.5mg buntanetap, 15mg buntanetap, 30mg buntanetap or a placebo, on top of their standard of care, for three months. In October 2022, the Company received permission from the FDA to proceed with the Phase 2/3 clinical study. In July 2021, the Company announced positive Phase 2 results demonstrating that treatment with buntanetap resulted in statistically significant improvements in cognitive function in patients with AD. Specifically, patients treated with buntanetap showed a 4.7-point or 30% improvement while the placebo group showed a 1.1-point improvement in ADAS-Cog11.2 Additionally, the WAIS coding test, which measures speed in movement and thinking, found that treated AD patients had a 6.6-point improvement in coding after buntanetap treatment. Additional information about the Phase 2/3 study is available here. About Buntanetap About Annovis Bio, Inc. For more information on Annovis Bio, please visit the Company’s website www.annovisbio.com and follow us on LinkedIn and Twitter. Forward-Looking Statements Media Contact: Investors Contacts: Kevin Gardner
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Company Codes: NYSE:ANVS |