Cell Penetrating Peptide Market Experiencing Rapid Growth

The global cell penetrating peptide market size was evaluated at USD 1.85 billion in 2023 and is expected to attain around USD 7.15 billion by 2032, growing at a CAGR of 16.2% from 2023 to 2032. The cell penetrating peptide market is experiencing rapid growth due to their versatility in delivering therapeutic agents into cells, enhancing treatments for cancer, inflammation, and other disorders. Increasing research efforts, demand for targeted drug delivery, and favorable regulatory environments are key drivers propelling market expansion. Technological advancements in peptide synthesis further contribute to the market’s growth.

Market Overview

The cell penetrating peptide market is witnessing rapid growth due to its ability to transport molecules across cellular membranes, offering a promising solution for enhancing the permeability of therapeutic proteins and peptides. CPPs have garnered significant attention for their high transduction efficiency and low cytotoxicity, making them an attractive option for overcoming limitations in drug delivery.

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CPPs remain valuable tools for cellular delivery, with the capability to transport proteins, nucleic acids, and drugs efficiently and non-toxically. These small peptide sequences can be custom-designed and synthesized to facilitate the transport of biomolecules, drugs, or nanoparticles into cells, presenting opportunities for innovation and growth in the pharmaceutical and biotechnology sectors.

· In March 2024, CordenPharma expanded its early clinical peptide manufacturing capabilities to introduce an integrated offer of peptide API to injectable drug products, targeting Investigational New Drug (IND) launches.

Key Insights

• North America dominated the global market with the largest share in 2023.

• Asia-Pacific is expected to expand at the highest CAGR between 2024 and 2033.

• By type, the protein-based cpps segment has held the largest market share in 2023.

• By type, the peptide-based cpps segment is anticipated to grow at a remarkable CAGR during the projected period.

• By application, the gene delivery segment contributed for the dominating share in 2023.

• By application, the molecular imaging segment is projected to expand at the fastest CAGR over the projected period.

• By end user, the pharmaceutical and biotechnology company segment captured the largest share in 2023.

• By end user, the contract research organizations (cros) segment is estimated to expand at the fastest CAGR over the projected period.

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Regional Stance

In 2023, North America dominated the cell-penetrating peptide market, holding the largest share. CPPs are widely utilized in North America as carriers for delivering therapeutic molecules to target sites. Notable CPPs such as TAT, penetratin, polyarginine, and MPG are actively researched for their drug delivery capabilities in the region. The robust investment in medical research and pharmaceutical development in North America has fueled ground-breaking discoveries and enhanced treatments across various domains. The patient-centered approach and healthcare freedom further strengthen the healthcare system in the United States, positioning it as a global leader in personalized medicine.

Asia-Pacific is projected to experience the fastest growth in the cell penetrating peptide market, with an estimated CAGR of 18.3% during the forecast period. This region boasts a thriving pharmaceutical industry, with China and Japan emerging as key players with market sizes of $152.79 billion and $82.67 billion, respectively. Asia-Pacific is establishing itself as a hub for innovation, particularly in the life sciences sector, with China, Japan, and Korea leading the charge in innovative pipeline assets. The region is witnessing a transition from generic production to the development of innovative technologies, with numerous biotech companies in Asia-Pacific spearheading this transformation.

Report Highlights

By Type

In 2023, the protein-based CPPs segment commanded a significant market share showcasing its dominance in the market. Cell penetrating peptides (CPPs), also referred to as protein transduction domains (PTDs), have revolutionized cellular membrane transport over the past 25 years. These peptides, ranging from 6 to 30 amino acids in length, efficiently deliver various cargoes across cellular membranes intact and functional, including peptides, proteins, nucleic acids, nanoparticles, and more, presenting vast opportunities in diagnostics and therapeutics. Despite promising pre-clinical results, clinical applications have been hindered by implementation challenges.

The peptide-based CPPs segment is poised for substantial growth during the forecast period. Peptide-bismuth bicycles, derived from readily available peptide precursors, are driving this growth due to their high accessibility and efficient cellular uptake demonstrated through live-cell microscopy. These sequences, with only three positive charges, exhibit comparable uptake to conventional CPPs, highlighting their potential for a wide range of applications. Bismuth(III)-triggered bicyclization further enhances cellular uptake, offering a promising avenue for future developments in the CPP market.

By Application

In 2023, the gene delivery segment claimed the largest market share on indication. CPP-based delivery platforms exhibit substantial potential for efficiently delivering various cargoes, including genes, proteins, and small molecule drugs directly to the cytosol. Gene medicines, such as pDNA, ASO, siRNA, miRNA, and mRNA, have long been studied, but their cellular uptake is inherently challenging due to electronic repulsion with anionic cell surfaces. CPPs offer a promising solution, with some studies demonstrating their effectiveness in gene delivery without additional reagents. CPPs, in combination with metal-organic frameworks (MOFs), are emerging as next-generation platforms for gene-based therapeutics.

The molecular imaging segment is poised for rapid expansion during the forecast period. While CPPs have seen limited use in molecular imaging, they hold significant potential. Molecular imaging techniques, including SPECT, PET, optical imaging, and MRI, rely on delivering contrast agents to intracellular and intranuclear targets, which is hindered by the cell membrane barrier. Incorporating membrane-transducing peptides, such as CPPs, into contrast agent design offers a promising strategy to overcome this challenge. The applications of CPPs in molecular imaging span across diverse modalities, including optical, magnetic resonance, and nuclear medicine imaging, presenting significant opportunities for innovation and growth in the field.

By End User

In 2023, the pharmaceutical and biotechnology company segment commanded the largest market share as an end user of cell-penetrating peptides (CPPs), particularly TAT peptide (TATp), which has demonstrated successful intracellular delivery of various cargos, including nanoparticulate pharmaceutical carriers such as liposomes and DNA. CPPs are favored by pharmaceutical and biotechnology companies for their ability to efficiently traverse cell membranes without specific receptor assistance and low toxicity, facilitating drug delivery into cells.

The contract research organizations (CROs) segment is poised for rapid expansion during the forecast period. CROs provide essential clinical trial services for pharmaceutical, biotechnology, and medical device industries, including regulatory affairs, clinical trial planning, site selection, recruitment support, data management, and project management. Rising research and development expenses, driven by the need for longer and more complex clinical trials, are compelling pharmaceutical companies and biotechnology firms to outsource these services to CROs.

However, as CROs take on more responsibilities in conducting clinical trials, they also face increased liability risks for participant injuries and financial losses that could potentially delay regulatory approval processes. Despite these challenges, the outsourcing trend presents valuable growth opportunities for contract research organizations across a spectrum of clinical research services and ancillary support functions.

Market Dynamics

Driver

Next-Generation Cell-Penetrating Peptides

The emergence of new-generation cell-penetrating peptides (CPPs) presents a promising and convenient alternative for clinical use compared to traditional methods such as chemical detergents, polymers, and viral vectors. While these conventional approaches may find utility primarily in vitro, CPPs demonstrate intrinsic selectivity for tumor tissues, offering potential applications in targeted drug delivery. Moreover, advancements in CPP design enable efficient escape from endosomes, enhancing their therapeutic efficacy. This trend is driving growth in the cell penetrating peptide market by expanding its applicability across various medical domains and fostering innovation in drug delivery technologies.

Restraint

Restraints in Cell Selectivity, Penetrating Efficacy, and In Vivo Stability

The optimization of cell selectivity, penetrating efficacy, and in vivo stability stands as critical drivers in advancing Cell-Penetrating Peptide (CPP) technology. Current CPPs often face limitations in cell selectivity, necessitating targeted administration to avoid adverse effects, while concerns over immunogenicity impede clinical applications. Additionally, improving endosomal escape mechanisms is pivotal for enhancing efficacy and stability. Overcoming these challenges is pivotal for unlocking the full potential and sustained growth of the cell penetrating peptide market.

Opportunities

Synergy of Cell-Penetrating Peptides (CPPs) and Nanoparticles (NPs) in Nanomedicine

The integration of nanotechnology in medicine heralds a new era, overcoming traditional drug delivery limitations. Nanomedicine, leveraging ultrafine nanoparticles (NPs) in the 1-100 nanometer range, has revolutionized bioimaging, drug delivery systems, and therapies. CPPs, serving as carriers for various payloads including proteins, peptides, and nucleic acids, exhibit enhanced performance when combined with nanomaterials. This synergy results in improved drug delivery precision, extended half-life, and heightened stability, offering immense opportunities in biomedical sciences. However, navigating the complex interplay between CPPs and NPs, including the selection of conjugation methods, is pivotal for optimizing intracellular vectors and maximizing peptide functionality, thereby paving the way for growth and innovation in the cell penetrating peptide market.

Recent Developments

• In January 2023, Revance announced that the U.S. FDA had accepted the Supplemental Biologics License Application (sBLA) for DAXXIFY (DaxibotulinumtoxinA-lanm) for Injection, intended for the treatment of Cervical Dystonia.

• In September 2022, Sarepta Therapeutics revealed that the FDA had lifted its clinical hold on SRP-5051, a potential treatment for Duchenne Muscular Dystrophy.

• In June 2023, IRBM extended its collaboration on peptide therapeutics with Merck & Co. Inc. in Rahway, NJ, USA.

Key players in the cell penetrating peptide market

• Bachem Holding AG

• Bio-Synthesis Inc.

• PolyPeptide Laboratories AB

• Tocris Bioscience

• Avidity Biosciences

• R&D Systems

• Novo Nordisk A/S

• CordenPharma

• Creative Peptides

• PEPperPRINT GmbH

• CPC Scientific Inc.

• Chemos GmbH & Co. KG

• ProImmune Ltd.

• GeneCust Europe

• PeptiDream Inc.

Market Segmentation

By Type

• Protein-based CPPs (TAT peptide, Penetratin, Antp)

• Peptide-based CPPs (Oligoarginine peptide, Polysrginine peptide, Transportan)

By Application

• Drug Delivery

• Gene Delivery

• Diagnostics

• Molecular Imaging

• Others (Vaccine development, Antimicrobial Therapy)

By End User

• Pharmaceutical and Biotechnology Company

• Contract Research Organization (CROs)

• Hospitals and Clinics

By Geography

• North America

• Europe

• Asia Pacific

• Latin America

• Middle East & Africa (MEA)

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