Rising prevalence of neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and brain tumors is one of the major factors supporting the global market revenue growth
Rising prevalence of neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and brain tumors is one of the major factors supporting the global market revenue growth
According to Emergen Research, the global blood-brain barrier (BBB) market size was USD 1.25 billion in 2020 and is expected to reach USD 7.40 billion in 2028 and register a revenue CAGR of 24.8% during the forecast period, 2021-2028.
Market Dynamics:
Substantial revenue growth of the global blood-brain barrier (BBB) market is attributed to factors such as rapidly growing global geriatric population, rising prevalence of neurological diseases such as Parkinson’s disease, Alzheimer’s disease, and Hunter’s syndrome, and increasing government and private investments in pharmaceutical research & development activities. Rising awareness of early diagnosis and treatment of neurological and central nervous system (CNS) disorders, such as brain tumor, epilepsy/seizures, catalepsy, encephalitis, and attention deficit/hyperactivity disorder (ADHD), and continuous advances in medical technologies are other major factors expected to drive market revenue growth to a significant extent over the upcoming years.
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Blood-brain barrier (BBB) is one of the main components of the neurovascular unit and serves as the blood-brain interface to mediate communication between the central nervous system and the periphery. It prevents pathogens and toxic chemical compounds from entering the brain, and thus, protects the brain against several blood-borne disorders. Blood-brain barrier is formed by the capillary wall’s endothelial cells, astrocytes, and pericytes, which are present in the capillary basement membrane. The blood-brain barrier also helps in blocking the flow of chemical compounds from the circulatory system to the brain or cerebrospinal fluid.
However, specialized drug uptake by the blood-brain barrier often complicates the treatment of brain disease. Some of the key blood-brain barrier permeation mechanisms include bispecific antibody RMT approach, passive diffusion, increasing permeability, and Trojan horse approach. Latest advances in drug delivery techniques enabling direct transfer of drugs to the cerebrospinal fluid, technological upgrades in magnetic resonance imaging (MRI), increasing applications of nanotechnology in neuroscience, and introduction of next-generation brain imaging technologies are factors that are expected to further drive the global market revenue growth.
COVID-19 Impact Analysis:
- Social distancing and restrictions severely disrupted businesses and operations
- Lockdowns caused disruptions in transportation and logistics
- Impacted manufacturing activities and mining operations globally
- Took a toll on economy of various countries
- Caused sudden and drastic downturn in economic activity
- Disrupted agriculture, fisheries, dairy, and other sectors
- Caused loss of employment and financial crisis
- Supply impacts were further compounded owing to reduced disposable income
- Emergence of variants continue to cause concerns and impact normal routines
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Scope of Blood-Brain Barrier (BBB) Market Research:
| Report Details | Outcome |
| Market size in 2020 | USD 1.25 Billion |
| CAGR (2018–2028) | 24.8% |
| Revenue forecast in 2028 | USD 7.40 Billion |
| Base year for estimation | 2020 |
| Historical data | 2018–2019 |
| Forecast period | 2021–2028 |
| Quantitative units | Revenue in USD Billion, and CAGR from 2018 to 2028 |
| Report coverage | Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
| Segments covered | Application, technology, end-use and by regions |
| Regional scope | North America; Europe; Asia Pacific; Central & South America; Middle East & Africa |
| Country scope | U.S.; Canada; Mexico; Germany; France; U.K.; BENELUX; Italy; Spain; Switzerland; Russia; Rest of Europe; China; Japan; South Korea; India; Rest of APAC Brazil; Rest of LATAM; Saudi Arabia; UAE; South Africa; Turkey.; Rest of MEA. |
| Key companies profiled | Allon Therapeutics, Inc., Angiochem Inc., Armagen Technologies, Inc., Bristol-Myers Squibb, BiOasis Technologies, Inc., Sanofi Genzyme, CarThera, Cephalon Inc., Nanomerics, and F. Hoffman La-Roche AG. |
| Customization scope | 10 hours of free customization and expert consultation |
Parkinson’s Disease Segment Accounted for Largest Revenue Share in 2020:
Based on application, the global blood-brain barrier (BBB) market is segmented into Alzheimer’s disease, epilepsy, Parkinson’s disease, multiple sclerosis, Hunter’s syndrome, and brain cancer. The Parkinson’s disease segment accounted for the largest revenue share in the global market in 2020. Rising prevalence of neurological disorders including Parkinson’s disease, growing awareness of early detection and treatment of neurological and CNS disorders, rising demand for advanced drugs and therapeutics for Parkinson’s disease are among the major factors supporting revenue growth of this segment.
Increasing Permeability Segment to Account for Fastest Revenue CAGR:
Based on technology, the global blood-brain barrier (BBB) market is segmented into bispecific antibody RMT approach, Trojan horse approach, increasing permeability, passive diffusion, and others. The increasing permeability segment is expected to register the fastest revenue CAGR in the global market over the forecast period. Rise in research & development activities for more advanced drugs & therapeutics for various neurological diseases, and growing significance of increasing permeability mechanism in blood-brain barrier permeation are among the key factors contributing to this segment’s revenue growth.
North America Market Accounted for Largest Revenue Share in 2020:
Among regional markets, the North America blood-brain barrier (BBB) market accounted for the largest revenue share in the global market in 2020. The regional market revenue growth is majorly attributed to factors such as increasing geriatric population, rising cases of neurological diseases including Alzheimer’s disease, Parkinson’s disease, and Hunter’s syndrome, growing awareness of early diagnosis and treatment of neurological and CNS disorders such as epilepsy/seizures, catalepsy, and brain tumor, and rise in public and private investments in pharmaceutical R&D activities. Presence of advanced healthcare facilities and leading market players in the region, including Bristol-Myers Squibb, Allon Therapeutics, Inc., and Angiochem Inc., further boosts the North America market revenue growth.
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Major Companies in the Global Blood-Brain Barrier (BBB) Market Include:
- Allon Therapeutics, Inc.
- Angiochem Inc.
- Armagen Technologies, Inc.
- Bristol-Myers Squibb
- BiOasis Technologies, Inc.
- Sanofi Genzyme
- CarThera
- Cephalon Inc.
- Nanomerics
- F. Hoffman La-Roche AG
For the purpose of this report, Emergen Research has segmented the global blood-brain barrier (BBB) market based on application, technology, end-use, and region:
Application Outlook (Revenue, USD Billion; 2018–2028)
- Alzheimer’s disease
- Epilepsy
- Parkinson’s disease
- Multiple sclerosis
- Hunter’s syndrome
- Brain cancer
Technology Outlook (Revenue, USD Billion; 2018–2028)
- Bispecific Antibody RMT Approach
- Trojan Horse Approach
- Increasing Permeability
- Passive Diffusion
- Others
End-use Outlook (Revenue, USD Billion; 2018–2028)
- Hospitals
- Surgical centers
- Research Institutes
- Others
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Region Outlook (Revenue, USD Billion; 2018-2028)
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- U.K.
- Italy
- Spain
- BENELUX
- Rest of Europe
- Asia Pacific
- China
- India
- Japan
- South Korea
- Rest of Asia Pacific
- Latin America
- Brazil
- Rest of Latin America
- Middle East & Africa
- Saudi Arabia
- U.A.E.
- South Africa
- Turkey
- Rest of Middle East & Africa
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