Cepheid and Sherlock Biosciences today announced a research collaboration between the two companies to explore the development of new cutting-edge molecular diagnostic tests. Leveraging Sherlock Biosciences’ engineering biology platform, SHERLOCK™, a CRISPR-based technology that can identify virtually any genetic target, new tests could be designed to run on Cepheid’s GeneXpert® Systems.
SUNNYVALE, Calif., and CAMBRIDGE, Mass., Feb. 28, 2020 /PRNewswire/ -- Cepheid and Sherlock Biosciences today announced a research collaboration between the two companies to explore the development of new cutting-edge molecular diagnostic tests. Leveraging Sherlock Biosciences’ engineering biology platform, SHERLOCK™, a CRISPR-based technology that can identify virtually any genetic target, new tests could be designed to run on Cepheid’s GeneXpert® Systems. The collaboration will focus on molecular diagnostic tests for infectious diseases and oncology, beginning with a proof-of-concept project focused on detection of coronavirus (SARS-CoV-2). “This partnership will allow us to explore utilizing Cepheid’s easy-to use-cartridge to further develop targeted molecular tests that better address outbreak scenarios,” said David H. Persing, M.D., Ph.D., Cepheid’s Chief Medical and Technology Officer. “With a global installed base of over 23,000 GeneXpert Systems, this technology could potentially be applied in multiple settings where actionable treatment information is needed quickly.” The companies plan to jointly pursue grant opportunities to further push development of newer molecular diagnostic tests to allow future GeneXpert users access to expanded test menu and capabilities. The companies may pursue opportunities in infectious diseases and oncology, including exploring how better to address outbreak scenarios. “SHERLOCK is an ideal platform for rapid response and development for any global outbreak, while also a powerful tool for affordable and rapid molecular diagnostic testing for routine assays,” said Rahul Dhanda, Sherlock’s Co-Founder, President and Chief Executive Officer. “We are excited to work on bringing our breakthrough CRISPR technology to Cepheid’s revolutionary GeneXpert platform, which should enable our companies to provide potential diagnostic solutions for a range of applications including infectious diseases and oncology. Initially, we will explore the compatibility of our technologies for coronavirus detection, while pursuing a broad set of solutions that enable users to make more effective decisions in both clinical and non-clinical settings worldwide.” About GeneXpert Systems and Xpert Tests About Cepheid About the SHERLOCK™ Platform SHERLOCK™ (Specific High Sensitivity Enzymatic Reporter unlocking) platform is an evolution of CRISPR, a powerful technology used to make precise edits in genetic code. SHERLOCK leverages CRISPR-Cas12 and Cas13 to detect the unique genetic fingerprints of virtually any DNA or RNA sequence in any organism or pathogen. Developed by company co-founders and licensed exclusively from the Broad Institute, SHERLOCK is a method for single molecule detection of nucleic acid targets. By programming a CRISPR molecule to detect the presence of a specific genetic signature in a sample or amplified target, SHERLOCK enables single molecule detection with high accuracy. When it finds those signatures, the CRISPR enzyme is activated and releases a robust signal. This signal can be adapted to work on a simple paper strip test, in laboratory equipment, or to provide an electrochemical readout that can be read with a mobile phone. About Sherlock Biosciences For Cepheid Media Inquiries: For Sherlock Biosciences Media Inquiries:
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