The Patient-Centered Outcomes Research Institute (PCORI) has approved funding awards totaling $258 million to support 26 new research studies.
| PCORI also approves $3.9 million for projects to implement research findings for care of appendicitis and serious mental illness WASHINGTON, July 26, 2022 /PRNewswire/ -- The Patient-Centered Outcomes Research Institute (PCORI) has approved funding awards totaling $258 million to support 26 new research studies. These studies aim to fill evidence gaps and improve health care decision making for a range of high-burden conditions among adults and children, including asthma, bone fractures, migraines, intellectual and developmental disabilities, and sinus infections.
Five comparative clinical effectiveness research (CER) studies focus on improving mental health and another four CER studies focus on heart conditions, which have both continued to worsen in the U.S. amid the COVID-19 pandemic. Additionally, PCORI today announced about $3.9 million for two projects that aim to promote wider, faster adoption of useful findings from completed PCORI-funded CER studies into typical care practices. “Reflecting priorities encapsulated in PCORI’s recently adopted Strategic Plan, today’s funding approvals are an important step in advancing PCORI’s work to generate and disseminate information that improves the quality and relevance of evidence available to help patients and all stakeholders make better-informed decisions about their health,” said PCORI Executive Director Nakela L. Cook, M.D., M.P.H. “Facing a complex health care system and many care options, patients need reliable information to help them understand which care options will work best for them in their particular circumstances.” $72 million to improve mental health care and outcomes The newly approved CER studies on mental health will expand an existing robust portfolio of PCORI-funded research examining the effectiveness of mental health care options for adults and children. One study will assess the comparative effectiveness of first- and second-line pharmacologic treatment strategies used to help people with bipolar disorder who are experiencing a major depressive episode. Funded for nearly $25 million, this large study aims to include 2,800 adult participants at 38 academic medical centers and community sites across the U.S. A second study will compare the benefits and potential harms of electroconvulsive therapy and intravenous ketamine for rapid treatment of acute suicidal depression. Funded at about $28.5 million, this large study aims to include 1,500 adults at 10 to 13 sites across the U.S. A third study will assess the comparative effectiveness of two interventions, text-messaging enhanced telehealth services and financial incentives, to increase outpatient addiction treatment among adults with opioid use disorder after they are discharged from an emergency department. Two other studies will:
$52.5 million to improve heart-related health care and outcomes Four newly approved CER studies will add to PCORI’s portfolio of funded research determining the effectiveness of cardiac health care options for adults. The largest will compare two therapies used to restore normal heartbeat patterns in millions of patients with both heart failure and reduced ejection fraction. It aims to determine whether His or left bundle branch cardiac pacing or biventricular pacing offers any advantages over the other. Funded at more than $31 million, the study aims to enroll over 2,000 adults at 55 sites in the U.S. and Canada. Three other studies will:
$3.9 million to promote the uptake of evidence from PCORI-funded research into practice These implementation projects will focus on:
PCORI also awarded funding to compare preventive therapies for migraines and bone fractures as well as multiple studies that focus on assessing ways to promote healthy aging. Details of the newly approved studies can be found on PCORI’s website. Details of all studies and projects approved for PCORI funding to date are available on the organization’s website. All funding awards were approved pending a business and programmatic review by PCORI staff and the issuance of formal award contracts. With these latest awards, PCORI will have invested more than $3.7 billion to fund patient-centered CER and support other projects designed to enhance CER methods and the infrastructure necessary to conduct CER rigorously and efficiently. About PCORI The Patient-Centered Outcomes Research Institute (PCORI) is an independent nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better-informed health care decisions. PCORI is committed to continuously seeking input from a broad range of stakeholders to guide its work.
SOURCE Patient-Centered Outcomes Research Institute |
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