Ventus Therapeutics Closes $100 Million Series B Financing

Proceeds to advance pipeline of small-molecule medicines against traditionally undruggable targets

WALTHAM, Mass. & MONTREAL--(BUSINESS WIRE)-- Ventus Therapeutics, Inc., a biotechnology company utilizing rational structure-based drug design to discover small-molecule medicines for high value and elusive targets, today announced a $100 million Series B financing led by RA Capital Management with participation from a select syndicate including BVF Partners L.P., Casdin Capital, Cormorant Asset Management, Fonds de solidarité FTQ, and Alexandria Venture Investments. Founding investor Versant Ventures also participated in the round, as did existing investor GV (formerly Google Ventures).

“This support from strong crossover investors will enable the next stage of evolution for Ventus as we build the resources to leverage the full potential of our platforms and product pipeline,” said Marcelo Bigal, M.D., Ph.D., president and CEO of Ventus. “We have made rapid and substantial progress over the last twelve months, including the emergence of the ReSOLVE™ platform and expansion of our pipeline. Ventus is on an exciting growth trajectory, as we continue to unlock high-value targets that have been elusive in the past and advance our lead products for patients with devastating diseases.”

Ventus’ drug discovery platforms combine computational technologies with leading-edge structural biology, protein engineering, biophysics and chemistry. Using two proprietary platforms, Ventus expands the set of drug targets accessible to small-molecule medicines by discovering and validating novel binding sites invisible to other approaches.

Proceeds from the Series B will be used to advance Ventus’ pipeline of novel medicines to treat diseases in multiple therapeutic areas and expand platform capabilities. The company’s most advanced programs are focused on critical targets of the innate immune system. Additional programs in autoimmune, inflammation, oncology and neurology indications create a diversified pipeline with opportunities for both partnerships and internal growth.

While the targets of Ventus’ lead program and other pipeline programs are undisclosed, the company’s second most advanced molecule targets NLRP3, a key mediator of pro-inflammatory cytokines IL-1b and IL-18. NLRP3 is implicated in many autoimmune diseases and other conditions characterized by aberrant inflammation. Ventus’ platforms enabled the stable expression of inactive subunits of NLRP3 and determination of the precise dynamic solvation structure of NLRP3’s binding pocket. Based on these breakthroughs, Ventus identified and optimized novel and differentiated NLRP3 inhibitors, including high potency and quality brain-penetrant molecules as well as peripherally restricted compounds.

Concurrent with this financing, Josh Resnick, M.D., managing director at RA Capital Management, will join the Ventus Board of Directors.

“Ventus is at the forefront of advances in structure-based drug design,” said Dr. Resnick. “We are excited that the company has proven its ability to drug challenging targets and look forward to continued progress by Ventus’ pipeline as the company seeks to bring new options to patients.”

ABOUT VENTUS THERAPEUTICS

Ventus Therapeutics is a biopharmaceutical company discovering and developing novel small-molecule medicines by pioneering new frontiers in structure-based drug discovery for biologically validated, but elusive, drug targets. Using two platforms – Structural Immunology and ReSOLVE™ – we are rapidly advancing a pipeline of new medicines to treat autoimmune diseases, inflammatory diseases and cancer. Our most advanced programs are enabled by our Structural Immunology platform, which unlocks rational, structure-based drug discovery for critical targets in innate immune pathways. Our ReSOLVE platform reveals novel druggable sites for traditionally undruggable targets, enabling us to expand our pipeline into oncology and neurology. Ventus was founded by Versant Ventures and the management team includes experienced biopharmaceutical executives and scientists who have delivered multiple approved medicines, as well as luminary academics across structural biology, immunology and computational chemistry. The company has locations in Boston, Massachusetts and Montreal, Canada. For more information, please visit www.ventustx.com and engage with us on Twitter @VentusTx or on LinkedIn.

ABOUT RA CAPITAL MANAGEMENT

RA Capital is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare and life science companies that are developing drugs, medical devices, and diagnostics. The flexibility of its strategy allows RA Capital to provide seed funding to startups and to lead private, IPO, and follow-on financings for its portfolio companies, both facilitating the crossover process and allowing management teams to drive value creation from inception through commercialization.

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