LOS ANGELES--(BUSINESS WIRE)--June 27, 2005--Hythiam, Inc. (NASDAQ:HYTM), a healthcare services management company that delivers to treatment providers proprietary administrative services and physiological protocols designed to treat substance dependence, announced today that addiction expert Jeffery Wilkins, MD, Vice Chairman, Department of Psychiatry and Mental Health at Cedars-Sinai Medical Center, will conduct a controlled study of Hythiam’s HANDS Protocols(TM) in the treatment of alcohol dependence. Dr. Wilkins is also Medical Director of Addiction Medicine and Director of Addiction Studies within the department’s Clinical Trials Unit. “With all of the recent attention on drug addiction, particularly methamphetamine dependence, it is important to remember that alcoholism is still the most serious substance abuse problem in the U.S.,” said Terren S. Peizer, Hythiam’s Chairman and CEO. “Hythiam is honored to be working with the prestigious Clinical Trials Unit of Cedars-Sinai’s Department of Psychiatry, which has chosen to study HANDS(TM) in a controlled setting. This study follows the recent announcement of a study of HANDS(TM) for the treatment of methamphetamine dependence.”