BridGene Biosciences, Inc. today announced Ping Cao, Ph.D., CEO and co-founder, will give a presentation at the 3rd Annual Ligase Targeting Drug Development Summit on Thursday, April 13, 2023, at 9:00 a.m. ET in Boston, Massachusetts.
CEO Ping Cao, Ph.D., to give presentation at Boston conference SAN JOSE, Calif., April 6, 2023 /PRNewswire/ -- BridGene Biosciences, Inc., a biotechnology company using a proprietary chemoproteomics technology to discover and develop small molecules for high-value, traditionally undruggable targets, today announced Ping Cao, Ph.D., CEO and co-founder, will give a presentation at the 3rd Annual Ligase Targeting Drug Development Summit on Thursday, April 13, 2023, at 9:00 a.m. ET in Boston, Massachusetts. BridGene has developed a highly efficient and unique approach to generate new Protac molecules with improved drug-like properties. Leveraging its live-cell IMTAC™ chemoproteomic platform for identifying small molecules against challenging targets, BridGene has successfully identified covalent ligands for more than 100 E3 ligases. BridGene’s specifically designed covalent library has enabled rapid transformation of selected screening hits into fully functional PROTACs through one-step click chemistry. Most E3 ligases are challenging to target due to lack of deep, hydrophobic pockets. Covalent small molecules can bind to them through covalent bond, rendering many more E3 ligases ligandable. This significantly expands the range of targetable E3 ligases. Furthermore, the novel covalent PROTACs developed by BridGene can improve kinetic stability, enhance degradation, and reduce the Hook effect. Most importantly, these new PROTACs have considerably smaller molecule weights and possess more drug-like properties, increasing their likelihood of oral bioavailability and allowing for faster optimization timelines. Details regarding Dr. Cao’s presentation are as follows:
About BridGene Biosciences Contact Tiberend Strategic Advisors, Inc. Media Dave Schemelia View original content to download multimedia:https://www.prnewswire.com/news-releases/bridgene-biosciences-to-present-at-ligase-targeting-drug-development-summit-301791420.html SOURCE BridGene Biosciences |