According to the global Downstream Processing market size is expected to surpass around USD 94.9 billion by 2030 from valued at USD 31.4 billion in 2021 and growing at a CAGR of 5.2% from 2022 to 2030.
According to the global Downstream Processing market size is expected to surpass around USD 94.9 billion by 2030 from valued at USD 31.4 billion in 2021 and growing at a CAGR of 5.2% from 2022 to 2030.
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Downstream Processing Market Key Takeaways:
- Chromatography systems accounted for the largest revenue share in 2021 owing to the high adoption of chromatography for biopharmaceutical purification
- The advent of single-use chromatography systems that bring an 80.0% reduction of the use of water and chemicals for buffer has further increased the adoption of chromatography for downstream processing of bio-therapeutics
- Filters are anticipated to grow at a lucrative rate over the forecast period. Efforts undertaken by the key players to develop intelligent membranes for purification & separation is fuelling the market growth
- Purification by chromatography accounted for the largest revenue share as it can be employed across all steps of a downstream process. The technique is also crucial in bioprocessing to obtain pure biologics
- Antibiotic production dominated the market in 2021 owing to the wide use of antibiotics for the treatment of a variety of clinical disorders including infectious diseases and cancer
- A rise in occurrences of antibiotic resistance also propels the industrial-scale development of novel antibiotic candidates
- North America dominated the global market in 2021 owing to the presence of large in-house biopharmaceutical manufacturing facilities
- Asia Pacific will register the fastest CAGR from 2022 to 2030 due to a rise in contract development services in emerging economies
Report Scope of the Downstream Processing Market
| Report Coverage | Details |
| Market Size | US$ 94.9 Billion by 2030 |
| Growth Rate | CAGR of 5.2% from 2022 to 2030 |
| Largest Market | North America |
| Fastest Growing Market | Asia Pacific |
| Base Year | 2021 |
| Forecast Period | 2022 to 2030 |
| Segments Covered | Product, technique, application and Region, |
| Companies Mentioned | Merck KGaA; Sartorius Stedim Biotech S.A; GE Healthcare; Thermo Fisher Scientific Inc.; Danaher Corporation; Repligen; 3M Company; Boehringer Ingelheim International GmbH; Corning Corporation; Lonza Group Ltd; Dover Corporation; Ashai Kasei; Ferner PLC; Eppendorf AG. |
A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. In February 2021, Rentschler Biopharma; a Germany-based contract development and manufacturing organization (CDMO) announced to start commercial manufacture, formulation, and downstream processing of CVnCoV COVID-19 candidate vaccine by CureVac. Similarly, Bayer also announced to manufacture 160 million doses of CVnCoV in 2022.
In January 2021, Thermo Fisher Scientific announced that it supported 250 projects for COVID-19 therapy as well as vaccine production in 2020. The company leverages its CDMO capabilities as well as its bioprocess consumables and equipment offerings for these projects. It has also partnered with Singapore and the U.S. government to expand its vaccine and therapy development capacities. Similar efforts have been made by EMD Millipore, Cytiva, Pall Biotech, and other companies to use their bioprocess offerings for COVID-19 therapeutics development.
A rise in R&D activities pertaining to advanced bioprocess technologies has resulted in the adoption of continuous downstream processing systems for multicomponent separations, perfusion chromatography systems, high-throughput process development, and high-resolution membrane systems. This has led to an increase in the need for improving bioprocessing technologies for addressing the purification bottleneck.
The number of CMOs in the market for downstream processing has increased as outsourcing helps pharmaceutical manufacturers reduce the high initial capital investment and procedure costs. CMOs help drug manufacturers in optimizing downstream purification, in addition to other processes such as cell culture preparation, chromatography, mixing, concentration, process monitoring, and disposable technologies.
Regional Insights
North America dominated the market for downstream processing with the largest revenue share of 35.6% in 2021 owing to government support for promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines.
In addition, key players operating in the market for downstream processing are expanding their foothold in this region. For instance, in December 2020, Thermo Fisher Scientific Inc. announced further expansion in Europe and North America for the commercial manufacturing of medicines, vaccines, and therapies. The expansion added 15 development and cGMP commercial production lines, leveraging the company’s robust quality standards for supporting a range of manufacturing capabilities.
In Asia Pacific, the market for downstream processing is expected to register the highest growth rate of 17.9% due to the rising investments by developers and consumers in the field of biotechnology. The presence of a large population base is driving the need for advanced medical facilities for which players are keen on implementing rapid analytical methods to support in-process designing and bioprocessing.
China dominated the market share in the Asia Pacific owing to the growing biopharmaceutical industry and increasing demand for medicines and vaccines. The biopharmaceutical industry is amongst the most active economic sectors in China and is marked with continuous revolution with modern biopharmaceutical equipment and process.
In addition, companies are entering into strategic partnerships for promoting vaccine and drug development in the country. For instance, in November 2020, Cytiva entered into deals with Zhifei, Wego, Jinbofor, and Clover to invest in manufacturing, bioprocess development, and research to accelerate therapeutics development in China. The company has a wide range of product portfolios including bioprocess filtration, chromatography products, and cell culture and fermentation processes.
Some of the prominent players in the Downstream Processing Market include:
- Merck KGaA
- Sartorius Stedim Biotech S.A
- GE Healthcare
- Thermo Fisher Scientific Inc.
- Danaher Corporation
- Repligen
- 3M Company
- Boehringer Ingelheim International GmbH
- Corning Corporation
- Lonza Group Ltd
- Dover Corporation
- Ashai Kasei
- Ferner PLC
- Eppendorf AG
Segments Covered in the Report
This research report offers market revenue, sales volume, production assessment and prognoses by classifying it on the basis of various aspects. Further, this research study investigates market size, production, consumption and its development trends at global, regional, and country level for the period of 2017 to 2030 and covers subsequent region in its scope:
- By Product
- Chromatography Systems
- Filters
- Evaporators
- Centrifuges
- Dryers
- Others
- By Technique
- Cell Disruption
- Solid-liquid separation
- Filtration
- Centrifugation
- Concentration
- Evaporation
- Membrane filtration
- Purification by Chromatography
- Formulation
- By Application
- Antibiotic Production
- Hormone Production
- Antibodies Production
- Enzyme Production
- Vaccine Production
By Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
Key Benefits for Stakeholders
- This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the global Downstream Processing industry analysis from 2022 to 2030 to identify the prevailing Downstream Processing industry opportunity.
- The market research is offered along with information related to key drivers, restraints, and opportunities.
- Porter’s five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
- In-depth analysis of the global Downstream Processing industry segmentation assists to determine the prevailing market opportunities.
- Major countries in each region are mapped according to their revenue contribution to the global market.
- Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
- The report includes the analysis of the regional as well as global Downstream Processing industry trends, key players, market segments, application areas, and market growth strategies.
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