Dragonfly Therapeutics, Inc., a clinical stage biotechnology company developing novel immunotherapies, today announced the April 13th publication of preclinical data in Cell Press’s Med supporting DF6002 as a promising treatment option for cancer patients.
The publication titled “An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses” was published on April 13th in Cell Press’s Med. WALTHAM, Mass., April 17, 2023 /PRNewswire/ -- Dragonfly Therapeutics, Inc., a clinical stage biotechnology company developing novel immunotherapies, today announced the April 13th publication of preclinical data in Cell Press’s Med supporting DF6002 as a promising treatment option for cancer patients. DF6002 is Dragonfly’s novel half-life extended interleukin-12 (IL-12) cytokine immunotherapy, currently in Phase 1 clinical development with dose escalation progressing successfully in patients as a monotherapy and in combination with nivolumab, in the U.S. and in Europe. Systemic IL-12 cytokine therapy was historically associated with severe toxicities due to its narrow therapeutic index. Dragonfly’s preclinical data demonstrates that DF6002 is well tolerated when administered systemically and results in potent anti-tumor responses in multiple preclinical models as monotherapy and in combination with checkpoint inhibitors. Dragonfly’s novel DF6002 IL-12 is designed for half-life extension which alters IL-12’s pharmacodynamic response profile and expands its therapeutic index. “We are excited about these findings, which provide compelling evidence supporting our ongoing Phase I clinical trial, which is evaluating the safety and tolerability of DF6002 in patients with advanced solid tumors,” said Joseph Eid, MD, Dragonfly’s President of Research and Development. “Given the encouraging profile we have seen both in preclinical models and in the clinic to date, we are accelerating DF6002’s development across a range of indications and combinations.” About DF6002 About Dragonfly For more information visit: DRAGONFLY MEDIA CONTACT: View original content to download multimedia:https://www.prnewswire.com/news-releases/dragonfly-therapeutics-announces-the-publication-of-preclinical-data-supporting-df6002-its-extended-half-life-il-12-cytokine-as-a-promising-treatment-for-cancer-301798329.html SOURCE Dragonfly Therapeutics, Inc. |