Obsidian Therapeutics

We are a clinical stage biotech company developing a novel, first-in-class, genetically engineered tumor infiltrating lymphocyte (“TIL”) cell therapy to deliver transformative outcomes for patients suffering from solid tumor malignancies and expand the reach of TIL therapy. We’re currently investigating OBX-115 and enrolling patients in an ongoing clinical trial in advanced or metastatic melanoma and non-small cell lung cancer (NSCLC). We engineer cytoTIL™ therapies using our proprietary cytoDRiVE® platform technology to express regulated therapeutic proteins to enhance anti-tumor activity.

Our aspirations are high, and we’re built to deliver – well-funded with blue chip investors, engaged field-leading advisors, strong partnerships with industry leaders, and a highly experienced, dynamic, innovative and collaborative team focused on delivering transformative therapies in areas of greatest clinical need.

We’re proud of our diverse talented team and committed to cultivating an environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research, Clinical and G&A teams are based in the heart of Cambridge, MA, and our Technical Development, Manufacturing & Quality team is based in our CMC facility in Bedford, MA. We offer competitive salary and benefits, and potential for employee ownership through stock options.

1030 Massachusetts Ave
Cambridge, MA 02138
  • Featured Employer

We know that patients are waiting, and we’re fiercely committed to delivering transformative therapies as fast as we responsibly can. We act with integrity and challenge ourselves and each other to bring our best every day.

We’re constantly questioning our assumptions, expanding our knowledge, generating and testing new ideas and approaches. Our curiosity drives our innovation.

We don’t believe in silos or hierarchies. We share ideas, strive and learn together, trust each other, and appreciate the value that every member of our team contributes.

We believe that healthy relationships and high performing teams develop when we can be our whole selves. We make time to connect, have fun, and get to know each other’s stories and interests.

Like the diversity of obsidian sources, our team brings varied backgrounds, identities, and experiences. Our collective knowledge, intellect, and energy is our greatest source of strength.

  • I’m looking forward to growing here. I’m learning more about cell therapy and using expertise I acquired in my years of studies to push our programs forward.
    Balazs Koscso, Sr. Scientist, Cell Therapy
  • I was really looking for three things: a mentor scientifically, a collaborative environment, and good culture. Here I found them all!
    Carmela Passaro, Principal Scientist, Cell Therapy
  • We have a real platform that can make a real difference in people’s lives, allowing us to dose in immuno-oncology what we couldn’t otherwise because it was too toxic.
    Dhruv Sethi, Senior Director, Discovery & DRD Technologies
  • It’s not just an opportunity but an expectation that we each have skills to contribute, and take initiative to expand, grow, and have a real impact.
    Mara Inniss, Director, Gene Editing Regulation
  • The #1 reason I joined was the science. I thought it was an interesting take on cell therapy, I liked the evidence that TILs work and I can see a benefit for the patients.
    Nicole Hsu, VP, Regulatory Affairs
BENEFITS

Diverse experiences, cross-functional collaboration, mentorship, training programs, and tuition reimbursement

  • We’re committed to gender pay equity
  • Employee stock options, 401K, and health savings accounts provide long-term value
  • Commuter benefit: reimbursement for public transport or parking
  • Career matrices (a tool for planning future development), and professional development goal setting
  • Generous coverage and low out of pocket costs for health and dental care (including a generous annual Health Savings Account contribution)
  • Perks to keep us well including gym, massage therapy, and meditation reimbursements, and team competitions like “Move it March”
  • We work hard to advance our mission, and are encouraged to relax and refresh under our flexible time off program
  • Six (6) weeks of fully paid bonding leave for parents to welcome a new child (birth, adoption, or foster care), in addition to fully paid medical maternity leave

We connect over company-sponsored lunches on our deck overlooking Mass Ave near the heart of Harvard Square, walks or rides on the Minuteman Bikepath right next to our Bedford facility, and through company sponsored social events

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