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28,760 Results for "roche boehringer mannheim".

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Drug development

Boehringer, Insilico Appear to Break Through Against IPF

Clinical trial results shared by Boehringer Ingelheim and Insilico Medicine showed improvement in idiopathic pulmonary fibrosis, an intractable lung disease for which current treatment options fail to stop progression, but the data were limited, leaving experts wanting.

September 24, 2024
·
4 min read
·
Heather McKenzie
Weight loss

Roche’s Obesity Pill Candidate Hit With Safety Concerns Despite Strong Efficacy Data

When doses were increased rapidly in a Phase I study, patients on Roche’s investigational oral GLP-1 receptor agonist experienced nausea, vomiting, constipation, diarrhea, as well as abdominal distension.

September 12, 2024
·
2 min read
·
Tristan Manalac
Earnings

Roche Beats Q3 Sales Estimates as CEO Voices Opposition to Novo Holdings’ Catalent Buyout

Jefferies analyst Peter Welford noted that Roche’s pharma group came just slightly ahead of consensus expectations, driven by strong performance of its multiple sclerosis therapy Ocrevus and eye injection Vabysmo.

October 23, 2024
·
3 min read
·
Tristan Manalac
Deals

Roche Inks Potential $1.8B Deal With Flare to Target Transcription Factors in Cancer

With $70 million upfront and more than $1.8 billion on the line, Roche will gain access to Flare’s drug discovery engine to bolster its oncology pipeline.

November 12, 2024
·
2 min read
·
Tristan Manalac
Phase III

Boehringer Aces Phase III Pulmonary Fibrosis Trial, Plans FDA Application

Boehringer Ingelheim’s investigational compound nerandomilast, which targets the PDE4B enzyme involved in fibrosis and inflammation in the lungs, met its primary endpoint in a late-stage study.

September 17, 2024
·
2 min read
·
Tristan Manalac
Immunology and inflammation

Roche Looks to Push Gazyva Into Lupus Nephritis With Promising Late-Stage Data

In the Phase III REGENCY study, Gazyva elicited superior complete renal response rates in patients with lupus nephritis versus placebo, positioning Roche’s therapeutic antibody for expansion into the indication.

September 27, 2024
·
2 min read
·
Tristan Manalac
Alzheimer’s disease

Roche Trims Another Alzheimer’s Prospect, Ending UCB Collabortion

Roche drops a third Alzheimer’s candidate this year, terminating a partnership with UCB just four years after agreeing to work together on new treatments for the neurological disease.

October 22, 2024
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1 min read
·
Annalee Armstrong
M&A

Roche Doubles Down on Breast Cancer With $850M for Regor’s CDK Inhibitors

The acquisition was featured Monday in Roche’s Pharma Day presentation, which also included projections of more than $3 billion in annual sales from three early-stage obesity and diabetes drugs.

September 30, 2024
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2 min read
·
Heather McKenzie
Approvals

Roche Gains PD-1 Edge on Merck With FDA Nod for Subcutaneous Tecentriq

Tecentriq Hybreza, which combines Roche’s Tecentriq with Halozyme Therapeutics’ Enhanze drug delivery technology, is being touted as the first and only subcutaneous anti-PD-(L)1 cancer immunotherapy.

September 13, 2024
·
2 min read
·
Tristan Manalac
Gene therapy

Roche Inks Potential $1B Gene Therapy Deal With Dyno, Eyes Neurological Diseases

With an upfront payment of $50 million from Roche, the partnership will leverage Dyno Therapeutics’ in vivo gene therapy delivery technology, which synthesizes virus capsids with better functionality and manufacturability.

October 24, 2024
·
2 min read
·
Tristan Manalac

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