Groundbreaking treatment approach shows promise in hard-to-treat cancers

April 11, 2024 |

2 min read

Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples.

MIAMI, April 11, 2024 /PRNewswire/ -- Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples. The results of the clinical study were published today in Nature Medicine.

This combined approach, developed by Florida International University (FIU) cancer researcher Diana Azzam, was used successfully for the first time to guide treatment of relapsed pediatric cancer patients in collaboration with First Ascent Biomedical and Dr. Maggie Fader at the Helen & Jacob Shaham Cancer & Blood Disorders Institute at Nicklaus Children’s Hospital in Miami.

It resulted in 83% of the children showing improvement, including Logan Jenner, 8, whose relapsed leukemia was successfully treated through Azzam’s new guided approach.

“The results are exciting because cancer that comes back is much harder to treat. Seeing improvement in 83 percent of patients is incredibly promising,” said Azzam, the assistant professor of environmental health sciences at the FIU Robert Stempel College of Public Health and Social Work and Society for Functional Precision Medicine board member who led the study. “This could be the way we turn cancer into a manageable disease.”

Approximately 2 million people are diagnosed with cancer in the United States each year, according to the National Cancer Institute. Nearly 30 percent (more than 600,000) are expected to die.

Breakthrough approach
The approach Azzam is pioneering has a few advantages over existing precision medicine processes, including faster results and more treatment options for doctors.

Azzam’s approach involves taking a sample of blood or tumor and enriching and processing the cancer cells in the lab in a way that closely resembles how they would normally grow in the body. Then the cancer is exposed to more than 120 FDA-approved drugs, including both cancer and non-cancer drugs. These drugs also may be tested in various combinations recommended by the clinical team. The best cancer destroyers emerge. The entire process takes about a week.

“The Azzam lab approach gets rid of the guesswork and delivers a list of the most effective drugs that the oncologist can work with,” said Stempel College Dean Tomás R. Guilarte, who is also one of the authors of the Nature Medicine article. “It’s accelerating our understanding of which cancer treatments work best for patients and their specific needs.”

Logan’s story
At the age of 3, Logan Jenner was diagnosed with acute myeloid leukemia. He received chemotherapy and bone marrow transplant. The cancer came back 14 months later.

Fader, Logan’s oncologist and co-investigator on the study, enrolled him in the clinical trial.