High-content screening refers to a technique used in biological research and drug discovery to discover substances such as peptides, small molecules, or RNAi that change the phenotype of a cell as desired.
High-content screening (HCS) refers to a technique used in biological research and drug discovery to discover substances such as peptides, small molecules, or RNAi that change the phenotype of a cell as desired. Phenotypic changes may include increase or decrease in the production of cellular components such as protein and/or alterations in the visual appearance of the cell.
High-content screening merges the molecular tools of cell biology with automated robotic handling, high-resolution microscopy, and automated analysis.
Global High Content Screening Market: Key Trends
The high-content screening market is driven by increasing funding and venture capital investments for cellular research, technological developments in HCS solutions, and cost containment in pharma R&D. However, factors such as high cost of HCS equipment and lack of expert and skilled personnel for operation of equipment are posing a challenge to the market’s growth. In addition, inadequate research infrastructure and insufficient funding for R&D in emerging nations is limiting this market’s growth.
The high-content screening market is segmented in terms of product, application, end user, and region. In terms of product, instruments, software, consumables, services, and accessories are the segments of this market. The segment of instrument held the leading share of the market in the recent past. The cell imaging and analysis segment held the leading share of the instrument segment of the HCS market. The instrument segment holds the leading share due to advances in instrumentation and automation techniques.
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On the basis of application, target identification and validation, toxicity studies, primary and secondary screening, compound profiling, and others are the segments of the HCS market. The segment of primary and secondary screening dominated the market in the recent past. The dominance of this segment is due to its large-scale usage in qualitative assays for lead specificity, evaluation of bioavailability, and exclusion of compounds with unintended modes of action.
In terms of end user, the HCS market is segmented into academic and government institutes, pharmaceutical and biotechnology companies, and contract research organizations. The segment of pharmaceutical and biotechnology companies held the leading share of the global HCS market in the recent past. The dominance of this segment is owing to the extensive usage of HCS in preclinical and clinical studies in the biotechnology and pharmaceutical industries.
Global High Content Screening Market: Market Potential
Beyond its conventional application in biological resaerch, high-content screening is being used in studying fat accumulation in cells. Researchers at the Department of Environmental Science at University of Georgia College of Public Health carried out studies to determine how exposure to phthalates in the form of nail polish or soap is related to the amount of fat stored in our bodies.
High-content screening employs image processing algorithms and computer machine language to measure multiple parameters objectively in no time.
Global High Content Screening Market: Regional Outlook
North America is the leading market for high-content screening trailed by the regions of Europe, Asia Pacific, Latin America, and the Middle East and Africa. High research and development expenditures, government support for research initiatives, and the presence of leading lifescience market players are attributed to the dominance of North America high content screening market.
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Global High Content Screening Market: Competitive Landscape
The key players in the global high content screening market include GE Healthcare, PerkinElmer Inc., Becton, Dickinson and Company, Danaher Corporation, and Thermo Fisher Scientific Inc. Some other players in the market include BioTek Instruments Inc., Tecan Group Ltd., Merck Millipore, Bio-rad Laboratories Inc, and Yokogawa Electric Corporation.
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