The current epidemic of obesity in developed countries should be a warning for health officials in the developing world with newly opened markets. Food manufacturers, restaurant franchising companies, food supply chains and advertisers collaborate to create environments in which extremely palatable, energy-dense foods and their related cues are readily available; however, people still have adaptive neural architecture best suited for an environment of food scarcity. In other words, the brain’s programming may make it difficult to handle the modern food ecosystem in a metabolically healthy way.