Rapidly rising prevalence of chronic and genetic diseases, increasing advancements in molecular biology techniques, and rising investments to accelerate cancer research studies are some key factors expected to drive market growth.
Rapidly rising prevalence of chronic and genetic diseases, increasing advancements in molecular biology techniques, and rising investments to accelerate cancer research studies are some key factors expected to drive market growth
According to Emergen Research, the global in-Situ Hybridization market size was USD 905.3 million in 2020 and is expected to reach USD 1,556.6 million in 2028 and register a steady revenue CAGR of 7.1% during the forecast period, 2020-2030.
Market Dynamics:
In situ hybridization is a molecular biology technique that uses labelled complementary DNA, RNA, or modified nucleic acid strands to precisely localize a particular segment of nucleic acid in a histologic sample. Nucleic acids when preserved adequately within a histologic specimen can be detected efficiently through in-situ hybridization by applying a complementary strand of nucleic acid to which a reporter molecule is attached. In situ hybridization is a powerful and robust tool in molecular biology that is extensively used for research and diagnosis. In-situ hybridization has significantly contributed to advancement in the study of gene structure and expression at the level of individual cells within a complex tissue environment and this is a key factor boosting its use in R&D and is expected to contribute to revenue growth of the market going ahead.
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In-situ hybridization plays a vital role in diagnosis and understanding of viral and neoplastic diseases, allow for morphologic identification of gene targets, provide valuable insights for hormone regulation, and detects cancer cells and these are some key factors expected to boost use of in-situ hybridization (ISH) in research and development activities and drive market revenue growth over the forecast period.
In situ hybridization enables accurate detection and precise localization of a specific nucleic acid sequence in an individual cells and combines three main attributes namely, higher sensitivity, precise anatomical localization, and the possibility of quantification. One of the major applications of in-situ hybridization is the efficient detection of specific messenger RNA molecules. ISH enables precise localization of the site of peptide synthesis and is also used to study the functional state of cells. Routine use of ISH in pathology makes use of non-radioactive probes. Techniques of ISH for detection of mRNAs has emerged as one of the powerful tool for analysing patterns of gene expression. ISH assays are also used to localize molecular information to specific tissues, cell types, and chromosomes, among others. Rising prevalence of genetic disorders, cancer, and other chronic diseases and rapid advancements in molecular biology research are some other factors contribute to revenue growth of the market growth.
COVID-19 Impact Analysis
- Social distancing and restrictions severely disrupted businesses and operations
- Lockdowns caused disruptions in transportation and logistics
- Impacted manufacturing activities and mining operations globally
- Took a toll on economy of various countries
- Caused sudden and drastic downturn in economic activity
- Disrupted agriculture, fisheries, dairy, and other sectors
- Caused loss of employment and financial crisis
- Supply impacts were further compounded owing to reduced disposable income
- Emergence of variants continue to cause concerns and impact normal routines
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Diagnostic Laboratories and Hospital Segment Revenue Growth to Support Market Growth:
Diagnostic Laboratories and Hospital segment is expected to account for a significantly large revenue share in the global market over the forecast period. Revenue growth can be attributed to increasing technological advancements, growing research and development activities in oncology, molecular biology, and regenerative medicine and rising prevalence of infectious and chronic diseases. Increasing population and growing investments by government and major companies are leading to rapid growth of medical sector and booming pharmaceutical, biotechnology industries, academic institutions, and various contract research organizations (CROs) across the globe. In addition, rising popularity of automation in diagnostic tests and diagnostic centres is another factor expected to drive revenue growth of the segment over the forecast period.
Kits and Reagents Segment Revenue to Expand Significantly:
Kits and Reagents segment is expected to register robust revenue CAGR over the forecast period attributable to rising adoption of In-Situ Hybridization (ISH) kits in diagnosis for early detection of specific proteins and nucleic acids from tissues, cells, liquids and other specimens. Demand for these advanced, efficient and precise ISH kits is increasingly rapidly for accurate disease diagnosis and augmenting pre-hybridization, post-hybridization and other hybridization treatment approaches. In addition, rapid adoption of ISH techniques and procedures are leading are boosting demand for straining solutions, buffers, blockers, among others. These factors are expected to drive revenue growth of the segment over the forecast period.
North America to Lead in Terms of Revenue Share:
North America is expected to account for largest revenue share in the global market attributable to increasing technological advancements and rising research and development activities by key market players, leading to designing of enhanced and innovative ISH techniques and procedures. Revenue growth in the region can be attribute to growing awareness regarding ISH procedures and companion diagnostic kits, rapid development of cancer centres and research organizations and rising prevalence of infectious diseases, cancer and genetic disorders. Moreover, rising investments by key market plyer such as Agilent Technologies and Abbott Laboratories are augmenting use of ISH in pharmaceutical, oncology and biotechnology sectors and are expected to drive market revenue growth over the forecast period.
Major Companies in the Market Include:
- Thermo Fisher Scientific
- Biocare Medical
- Agilent Technologies
- Abbott Laboratories
- Abnova Corporation
- Hoffmann-La Roche Ltd.
- Merck KGAa
- Danaher Corporation
- Bio SB
- BioGenex Laboratories
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For the purpose of this report, Emergen Research has segmented the global in-situ hybridization market based on the technology, application, product type, end-use, and region:
Technology Outlook (Revenue, USD Million; 2018–2028)
- Fluorescence In-Situ Hybridization (FISH)
- Chromogenic In-Situ Hybridization (CISH)
Application Outlook (Revenue, USD Million; 2018–2028)
- Cancer Diagnostic
- Infectious Disease
- Immunology
- Neuroscience
- Cytology
- Others
Product Type Outlook (Revenue, USD Million; 2018–2028)
- Kits & Reagents
- Probes
- Instruments
- Software
- Others
End-use Outlook (Revenue, USD Million; 2018–2028)
- Diagnostics Laboratories and Hospitals
- Pharmaceutical & Bio-technology
- Academic & Research Institute
- Contract Research Organizations (CRO)
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Regional Outlook (Revenue, USD Million; 2018–2028)
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- U.K.
- France
- Italy
- Spain
- BENELUX
- Rest of Europe
- Asia Pacific
- China
- India
- Japan
- South Korea
- Rest of APAC
- Latin America
- Brazil
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- U.A.E.
- South Africa
- Turkey
- Rest of MEA
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