Agents believed to selectively “restart” genes that limit cancer’s growth -- a potential treatment option already in early clinical studies -- instead turn off as many genes as they turn on, a team of researchers from the National Cancer Institute and Johns Hopkins has discovered."We don’t know what effect all these changes might have, but it’s clear that when scientists are looking only at the agents’ effects on a particular gene or a few particular genes, they aren’t seeing the whole picture,” says Andrew Feinberg, M.D., M.P.H., King Fahd Professor of Medicine at Johns Hopkins. Their report appears in the October issue of Cancer Cell.
