Merck Sharp & Dohme Release: New Vaccine Production Facilities in the Netherlands to Respond to the Broad Acceptance of Gardasil® in Europe

Haarlem, 29th October 2008 – Today, Merck Sharp & Dohme (MSD), parent company of Sanofi Pasteur MSD and manufacturer of Gardasil®, inaugurates new state of the art filling and packaging facilities for Gardasil® in their vaccine production plant in Haarlem, the Netherlands. This will considerably expand the global supply of Gardasil® and enable the filling and packaging of all Gardasil® doses destined for Europe to be done in Haarlem.

The investment of €30 million adds to a commitment of €200 million earlier this year in a new strategic vaccine production site in Carlow, Ireland.

"These facilities respond to the strong endorsement of Gardasil® in Europe and worldwide and also exemplify our commitment to investing in Europe to provide the highest quality vaccines possible," says Anne-Marie Graffin, Vice President Business Management at Sanofi Pasteur MSD. "Both Merck and Sanofi Pasteur MSD, Merck's European vaccine joint-venture with sanofi-aventis, are deeply rooted here."

Gardasil® is the only four-type (6,11,16,18) human papillomavirus (HPV) vaccine. In addition to strong and sustained cervical cancer protection, Gardasil® protects from cervical, vulvar and vaginal pre-cancer, and from genital warts caused by HPV types 6, 11, 16 and 18. These four types together cause the vast majority of HPV-related genital diseases.1,2,3

Today, two years after the first approval in 2006, Gardasil® is approved in 107 countries and vaccination with Gardasil® is widely implemented with 34 million doses distributed worldwide (including 8 million doses in Western Europe*)† and 90% global market share. ‡ These figures reflect the strong endorsement by experts, regulators, health authorities, physicians as well as parents and daughters.

HPV vaccination is now recommended in 18 of the 19 European countries in which Sanofi Pasteur MSD markets Gardasil®, and is funded or due to be funded soon in 17 of them§. The vaccine is also recommended and funded in the US, Australia, New Zealand and Canada.

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