NephroSant™ announced that the Journal of Clinical Medicine has published real-world data (RWD) that provides insight into how changes in allograft health are reflected in specific ranges of QSant™ scores.
SAN FRANCISCO, March 3, 2022 /PRNewswire/ -- NephroSant™ a biotechnology company dedicated to accelerating the diagnosis of early kidney damage in native and transplanted kidneys, with a mission to significantly improve global kidney health, announced that the Journal of Clinical Medicine has published real-world data (RWD) that provides insight into how changes in allograft health are reflected in specific ranges of QSant™ scores. QSant is a non-invasive home collection that analyzes biomarkers of kidney transplant rejection in urine and provides a score from 0-100 that can inform treatment decisions. “We developed QSant to aid physicians in the early detection of rejection in order to protect patients from an untimely loss of a transplanted kidney” explained NephroSant Founder, Minnie Sarwal, MD, PhD. “Results from this RWD study provide important insights for physicians when interpreting QSant scores. By understanding how these scores relate to a patient’s rejection risk, physicians can assess their patients’ evolving needs for immunomodulation throughout the continuum of their post-transplant care.” Results from this RWD study of 235 adults and children who received kidney transplants at 11 U.S. transplant centers, show that QSant scores of <32 indicate stable immune quiescence. Importantly, not only does a score below 32 indicate the health of a patient’s kidney transplant, but it may negate the need for invasive biopsies. The study results identified a QSant Score of between 32 and 55 to indicate a state of alloimmunity flux. A decreasing gradient in this range may indicate a resolution of rejection following successful immunomodulation. In contrast, patients with an increasing gradient between 32 and 55 may be advancing towards an allograft rejection event. Lastly, a QSant score over 55 indicates histologically concordant acute rejection. The open-access article, titled: “Through the looking glass: Unravelling the stage-shift of acute rejection in renal allografts” (doi.org/10.3390/jcm11040910) was published online in the peer-reviewed Journal of Clinical Medicine in February 2022. NephroSant developed QSant as a Laboratory Developed Test (LDT), which is now covered by Medicare under a local coverage determination (LCD) issued by the Centers for Medicare & Medicaid Services (CMS) Molecular Diagnostics Program (MolDX). About Chronic Kidney Disease and Transplantation About QSant™ When ordered by a treating physician, QSant is shipped directly to the patient’s home. A single urine sample is collected and shipped back directly to the NephroSant lab for analysis. NephroSant’s proprietary algorithm generates a personalized “Q-Score™,” which quantifies risk of rejection personalized to a particular patient. This score is delivered directly to the physician to inform post-transplant care. QSant has been studied through NephroSant’s Early Access Program (EAP) conducted within a select group of 11 transplant centers in the US. Feedback from physicians and patients surveyed during the EAP supports QSant’s accuracy for rejection detection, ease of use and convenient in-home collection. About NephroSant™ Contacts Media, Patients, Providers: View original content:https://www.prnewswire.com/news-releases/nephrosant-publishes-real-world-evidence-showing-potential-to-improve-the-detection-of-early-rejection-events-with-qsant-301494646.html SOURCE NephroSant |