CAMBRIDGE, Mass.--(BUSINESS WIRE)--Nimbus Discovery LLC, a biotechnology company discovering novel medicines against exciting but previously inaccessible drug targets, presented preclinical data today that show that the novel Nimbus IRAK4 inhibitor, ND-2158, when combined with the Bruton’s tyrosine kinase (BTK) inhibitor, ibrutinib, the PI3Kdelta inhibitor GS-1101 or the Syk inhibitor P505-15, works synergistically to induce selective cell death in hematological tumors with L265P activating MyD88 mutation. This genetically-defined patient population can be identified in the clinic prior to treatment, increasing the potential for a positive response.
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