The public-private research partnership, led by Prof. David Brayden, a senior scientist at BEACON based in UCD and Dr Nora Khaldi, CSO & Founder of Nuritas, has the potential to be a game changer for the biopharma industry and patients alike.
Dublin, Ireland, 12 February 2019. When we take a drug in a tablet or capsule form, does it sustain in our digestive system long enough so that the active ingredient reaches our blood to relieve pain or fight infection effectively, especially when compared to receiving the same drug as an injection? Scientists at Nuritas and SFI’s BEACON Bioeconomy Research Centre have joined forces to investigate this question of oral bioavailability in naturally occurring molecules, called peptides, from food or food by-products. The public-private research partnership, led by Prof. David Brayden, a senior scientist at BEACON based in UCD and Dr Nora Khaldi, CSO & Founder of Nuritas, has the potential to be a game changer for the biopharma industry and patients alike.
Nuritas uses their artificial intelligence (AI) platform to identify natural peptides from food or food by-products. Peptides are the major signalling molecules in humans and as such have numerous health benefitting functions such as anti-inflammation, anti-microbial and blood glucose regulation. To get the most of these bioactive molecules, they must last longer in the body, after swallowing and passing through the intestine and liver, in order to reach the blood stream intact.
Prof Brayden, a world leading expert in drug delivery and oral bioavailability, will be using established and innovative techniques to create oral dosage forms of natural peptides discovered by Nuritas.
“To be able to take food-derived natural peptides and create an oral delivery system with pharmaceutical applications will be a major advance for both the biopharma industry and patients. This is a holy grail of the industry and something they have been working to develop for decades. Such advances have the potential to reduce industry production costs. Patients would also have the convenience of being able to take tablets or capsules, thereby reducing hospital visits, which is likely to improve treatment compliance and outcomes. We would also be advancing the development of our bioeconomy by using food-derived natural peptides”, said Prof. David Brayden.
“Although very efficacious, many peptides have low oral bioavailability, so identifying new ways to improve their delivery to the blood stream will allow diseases reliant on injectables, such as diabetes, to be treated with drugs in tablet or capsule form. This in a way helps us to disrupt beyond the discovery of peptides into improved delivery of efficacious oral peptides. We will be doing this through computationally understanding the structural, physical and chemical requirements of bioavailable peptides. This can change the way drugs are discovered as we want our AI system to integrate bioavailability at the very start of the prediction, reducing the risk of failure during later drug development phases. “said Dr Nora Khaldi.
BEACON is working to revolutionise the bioeconomy by addressing national and global societal challenges. The centre does this through strategic research developed in collaboration with industry.
“This project is a perfect example of using advanced technology to generate bio-based products of enhanced societal and economic value from our natural resources, which is the core focus of the centre’s work’, said Prof. Kevin O’Connor, Director of BEACON.
“By bringing together Nuritas’ AI technology and Prof Brayden’s oral peptide delivery expertise, this project could have a major global impact on drug development”, concluded Dr Nora Khaldi.
To learn more, please watch our short informational video here.
The project is currently seeking to recruit a postdoctoral researcher with drug delivery expertise, closing Thursday 28 February.
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About SFI BEACON Bioeconomy Research Centre
BEACON harnesses the wealth of Ireland’s natural resources on land and in the sea for the development of a sustainable circular Irish bioeconomy, enabling vibrant sustainable communities. BEACON collaborates closely with industry across the agri-food, forestry, marine and fisheries sectors to convert residues and side streams created during primary production processes to higher value products (including food/feed ingredients), creating new business opportunities and new value chains, and enabling partners to diversify and increase resource efficiency. Through industry partnerships they are stimulating rural regeneration, curtailing environmental damage, extracting healthy nutritional supplements, reducing import dependency, and developing human capital.
For more information visit: www.beaconcentre.ie
About Nuritas
Founded in 2014 by mathematician and bioinformatician Dr. Nora Khaldi, Nuritas is the first company in the world to demonstrate that AI can accelerate the discovery of a healthcare product from concept to market in less than 3 years. Nuritas is a discovery platform for active peptides that can prevent or treat disease with industry leading speed and accuracy. It is successfully doing so currently in collaboration with a number of industry leading multinationals. The multi-award winning company is changing the landscape of drug discovery by identifying novel peptides using a proprietary artificial intelligence (AI) platform, with in-silico predictions validated by their in-house laboratory and multidisciplinary team of scientists.
For more information visit: www.nuritas.com
About Science Foundation Ireland
Science Foundation Ireland (SFI) is the national foundation for investment in scientific and engineering research. It funds oriented basic and applied research in the areas of science, technology, engineering, and mathematics (STEM) which promotes and assists the development and competitiveness of industry, enterprise and employment in Ireland. The Foundation also promotes and supports the study of, and engagement with STEM, and promotes an awareness and understanding of the value of STEM to society and to the growth of the economy. See www.sfi.ie.
