Nuvalent Appoints Emily Drabant Conley, PhD, to Board of Directors

Industry-leading genomics expertise supports Nuvalent’s advancement as a clinical-stage precision oncology company

CAMBRIDGE, Mass., Feb. 3, 2022 /PRNewswire/ -- Nuvalent, Inc. (Nasdaq: NUVL), a biotechnology company creating precisely targeted therapies for clinically proven kinase targets in cancer, today announced the appointment of Emily Drabant Conley, Ph.D., Chief Executive Officer of Federation Bio, to its Board of Directors.

“I’m impressed by Nuvalent’s focus on compelling science and only advancing opportunities with best-in-class potential, both of which I believe position the company to deliver on their goal of new therapies that may help physicians and their patients stay one step ahead of cancer,” said Dr. Conley. “Additionally, I look for authenticity as a hallmark of strong leadership and am inspired to have found this clearly in CEO Jim Porter and the cultural foundation at Nuvalent.”

Dr. Conley’s work has contributed to industry-shaping advances in genomics that empower patients and clinicians with actionable health data. Prior to joining Federation Bio, she spent over a decade at 23andMe where, as Vice President of Business Development, she was instrumental in powering the company’s growth from 30 employees into a household name.

“Dr. Conley’s depth of experience in diagnostics and genomics is a natural complement to our focus on therapeutic targets that are oncogenic drivers as we move into the next phase of our journey as a clinical-stage company,” said James Porter, Ph.D., Chief Executive Officer at Nuvalent. “We are honored to grow our board with her unique perspective encompassing the development of both cutting-edge diagnostics and oncology therapeutics, and her passion for realizing a future where these tools represent the standard of care for all patients.”

Nuvalent is currently enrolling patients in the Phase 1 portion of its ARROS-1 study, a Phase 1/2 clinical trial evaluating its lead candidate NVL-520, a ROS1-selective inhibitor, in patients with advanced ROS1-positive non-small cell lung cancer and other solid tumors. A clinical trial for its parallel lead candidate NVL-655, an ALK-selective inhibitor, is expected to be initiated in the first half of 2022. NVL-520 and NVL-655 are designed with the aim to address the clinical challenges of emergent treatment resistance, CNS adverse events, and brain metastases that may limit the use of currently available kinase inhibitors.

“Broad education about and access to cancer genomic testing are critical to identifying and matching patients with targeted treatment opportunities, including those now available through compelling clinical trials such as the ARROS-1 study,” said Dr. Conley. “I look forward to working with the Nuvalent team to help drive the integration of genomics into clinical care with the goal of allowing more patients to benefit from their precisely targeted therapies.”

As the CEO of Federation Bio, Dr. Conley is pioneering the development of engineered bacterial-cell therapies to treat a wide range of diseases, from metabolic disorders to cancer. She has received numerous awards and honors during her career, including selection to Endpoints News’ 20 Biopharma Leaders Under 40, Business Insider’s 30 Leaders Under 40, and Google Ventures’ 25 Women Shaping the Future of Technology. Prior to joining 23andMe, Dr. Conley was a research fellow at the National Institutes of Health and is co-author of more than 35 academic publications. She received her doctorate in neuroscience from Stanford University School of Medicine, after earning a B.A. in psychology and business from Vanderbilt University. In addition to her recent appointment at Nuvalent, Dr. Conley serves on the boards of Medrio and TMRW Biosciences.

About Nuvalent

Nuvalent, Inc. (Nasdaq: NUVL) is a biopharmaceutical company focused on creating precisely targeted therapies for patients with cancer, designed to overcome the limitations of existing therapies for clinically proven kinase targets. Leveraging deep expertise in chemistry and structure-based drug design, we develop innovative small molecules that have the potential to overcome resistance, minimize adverse events, address brain metastases, and drive more durable responses. Nuvalent is advancing a robust pipeline with parallel lead programs in ROS1-positive and ALK-positive non-small cell lung cancer (NSCLC), along with multiple discovery-stage research programs. We routinely post information that may be important to investors on our website at www.nuvalent.com. Follow us on Twitter (@nuvalent) and LinkedIn.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Nuvalent’s strategy, business plans, and focus; the clinical development program for NVL-520 and NVL-655 and the timing thereof; the potential clinical effect of NVL-520; the design and enrollment of the ARROS-1 study and the timing thereof; the potential of Nuvalent’s pipeline programs, including NVL-520 and NVL-655; Nuvalent’s research and development programs for the treatment of cancer; risks and uncertainties associated with drug development; and the expected benefits from the appointment to the Nuvalent Board of Directors of Dr. Conley. The words “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “aim,” “goal,” “intend,” “believe,” “expect,” “estimate,” “seek,” “predict,” “future,” “project,” “potential,” “continue,” “target” or the negative of these terms and similar words or expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. You should not place undue reliance on these statements or the scientific data presented.

Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties, and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks that Nuvalent may not fully enroll the ARROS-1 study or it will take longer than expected; unexpected concerns that may arise from additional data, analysis, or results obtained during the ARROS-1 study; the occurrence of adverse safety events; risks of unexpected costs, delays, or other unexpected hurdles; risks associated with: the impact of COVID-19 on countries or regions in which Nuvalent has operations or does business, as well as on the timing and anticipated timing and results of its clinical trials, strategy, and future operations, including the ARROS-1 study; the timing and outcome of Nuvalent’s planned interactions with regulatory authorities; and obtaining, maintaining, and protecting its intellectual property. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2021, as well as any subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements represent Nuvalent’s views only as of today and should not be relied upon as representing its views as of any subsequent date. Nuvalent explicitly disclaims any obligation to update any forward-looking statements.

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SOURCE Nuvalent, Inc.

Company Codes: NASDAQ-NMS:NUVL