Leiden, the Netherlands, 4 October 2006 – OctoPlus, the drug delivery and development company,
announces today that it has raised gross proceeds of approximately €20 million (approximately €18
million, net of estimated expenses) through its initial public offering (the “Offer”) on Euronext
Amsterdam of 4,301,076 newly issued ordinary shares with a nominal value of €0.12 per share (“New
Shares”). The New Shares will be placed at a price of €4.65 per New Share and are expected to start
trading as of 12:30 p.m. Amsterdam time on 4 October 2006. Based on the Offer Price as stated
below, the Company would have a market capitalization on commencement of trading of
approximately €75 million.