Peter MacCallum Cancer Centre (“Peter Mac”) and Cartherics Pty Ltd (“Cartherics”) announced today they have entered into a Collaborative Development Program Agreement (CDPA) to develop Cartherics’ proprietary autologous CAR-T cell therapy (CTH-004) for the treatment of ovarian cancer.
Peter MacCallum Cancer Centre (“Peter Mac”) and Cartherics Pty Ltd (“Cartherics”) announced today they have entered into a Collaborative Development Program Agreement (CDPA) to develop Cartherics’ proprietary autologous CAR-T cell therapy (CTH-004) for the treatment of ovarian cancer.
The clinical trial to be conducted by Peter Mac will be the first time a CAR-T cell therapy product containing the genetic modifications incorporated into CTH-004 has been tested in humans.
Ovarian cancer is Australia’s most lethal gynaecological cancer, taking more than 1,000 lives each year. With a five-year survival rate of only 49%, there is an urgent need for research to give those diagnosed a better chance of survival.
Professor Simon Harrison, Director of the Centre of Excellence in Cellular Immunotherapy at Peter Mac, said “CAR T-cell therapy is a powerful immunotherapy that is uniquely tailored for each patient and which re-purposes their own T-cells to fight their cancer.”
“It has emerged as a new treatment paradigm in blood cancer where it can produce complete responses, meaning their blood cancer has disappeared, in patients who have exhausted all other treatment options.
“The Centre of Excellence in Cellular Immunotherapy at Peter Mac is part of an international research effort to expand CAR T-cell therapy beyond blood cancer, and we’re excited to be working with Cartherics to stage this first-in-human clinical trial in ovarian cancer.”
Professor Alan Trounson, CEO of Cartherics, said “There are many patients needing help to control ovarian cancer and CAR-T therapy could be a game changer for them. It is our priority to ensure this potential therapy is tested in clinical trials as soon as possible.”
Cartherics Board Advisor, Heather Hawkins said “As an ovarian cancer survivor and patient advocate, I am truly grateful for the vision, skill and dedication of the Cartherics team who are working tirelessly - seeking to improve the survival rates and the quality of life of women diagnosed with ovarian cancer. This announcement brings a real sense of progress and hope in this space.”
There is an unmet need for new treatments options for patients with ovarian cancer as more than 80% of ovarian cancer patients experience a recurrence after initially having successful surgery and treatment.
The key aspects of the collaborative research are to develop clinical-scale manufacturing of CTH-004 and conduct a Phase I clinical trial. This program will be led at Peter Mac by the Centre of Excellence in Cellular Immunotherapy, with manufacturing being conducted at Peter Mac’s manufacturing partners Cell Therapies Pty Ltd.
The clinical trial will initially enroll 6-12 patients with ovarian cancer who have failed prior treatment with chemotherapy. The primary goal of the clinical trial is to investigate the safety of CTH-004 in this patient population.
Cartherics and Peter Mac recently announced a collaboration for another Cartherics autologous CAR-T product, CTH-001. Based on pre-clinical data, the collaborators have agreed that Peter Mac will focus its efforts on CTH-004.
ENDS
About ovarian cancer
Ovarian cancer is a disease where some of the cells in one or both ovaries start to grow abnormally and develop into cancer. Approximately 314,000 new ovarian cancer cases and 207,000 deaths occurred globally in 2020.[1] Ovarian cancer does not usually cause symptoms in its early stages and is often diagnosed at an advanced stage. It is most often treated with surgery and chemotherapy either on their own, or in combination. There is an unmet need for new treatment options for patients with ovarian cancer as more than 80% of ovarian cancer patients experience a recurrence after initially having successful surgery and treatment.[2]
About Peter MacCallum Cancer Centre
Peter MacCallum Cancer Centre is a world leading cancer research, education and treatment centre and Australia’s only public health service solely dedicated to caring for people affected by cancer. The centre has 3,300 staff, including more than 750 laboratory and clinical researchers, all focused on providing better treatments, better care and potential cures for cancer.
The Centre of Excellence in Cellular Immunotherapy at Peter Mac supports, develops and translates novel cell and gene therapies and is able to deploy its established suppliers and manufacturing partners such as Cell Therapies Pty Ltd to enable the use of these products in clinical trials for patients with cancer.
About Cell Therapies Pty Ltd (“CTPL”)
Cell Therapies is a leading provider of onshore cGMP contract manufacturing and deployment services for cell and gene therapy products in the Asia Pacific. Building on more than 20 years’ experience, and strategic partnerships within the ecosystem of the Peter MacCallum Cancer Centre, Cell Therapies provides a complete process development and GMP manufacturing and supply service from translational studies through to large-scale commercial supply. This unique capability positions Cell Therapies to serve as a single access point for regional deployment of cellular therapies for our clients.
About Cartherics
Cartherics is a privately held biotechnology company based in Melbourne, Australia that is rearming the body’s immune system to fight cancer. It is developing cell-based immunotherapies for the treatment of cancer, with a portfolio of CAR-T and CAR-NK cell products. The Company’s allogeneic (“off-the-shelf”) cell platform is based upon induced pluripotent stem cells (iPSCs) generated from donated cord blood that can be differentiated into NK cells, T cells and other cells of the immune system. The iPSCs are genetically engineered to provide enhanced function for the derived NK and other immune cells.
The Company is also developing autologous CAR-T cell therapies. These use the patient’s own immune system T cells, which are modified to be effective against the patient’s cancer cells. CTH-004 is created by genetically modifying patient T cells to insert a chimeric antigen receptor (CAR) to target a marker (TAG-72) on ovarian cancer cells and delete genes that are involved in suppression of T cell function.
For More Information
Media Contacts
Peter MacCallum Cancer Centre:
Communications
Phone: +61 417 123 048
Email communications@petermac.org
Cartherics:
Christine Filippis
Phone: +61 419 119 866
Email: christine@teraze.com.au