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Downstream Processing Market Key Takeaways
• North America dominated the global market with a major market share of 36.14% in 2023.
• Asia-Pacific is expected to expand at the fastest CAGR between 2024 and 2033.
• By Application, the antibiotic production segment generated revenue share of 34% in 2023.
• By Technique, the monoclonal antibody medication segment contributed more than 42% of revenue share in 2023.
• By Product, the thalassemia segment has held the biggest revenue share of 43% in 2023.
Downstream processing is an important series of events that obtains a high-quality purified product through industrial production. The downstream processing market revolves around several industrial processes, production equipment, and product recovery strategies. The biopharmaceutical industries focus on increasing the yield and recovery of products by reducing production costs. These products include proteins, enzymes, antibodies, antibiotics, vaccines, and other pharmaceutical products that are obtained in a highly purified form. The choice of downstream processing techniques depends on the type of biological material used to get a desired final product.
Filtration, centrifugation, chromatography, etc. are the widely used biotechniques in downstream processing. The well-equipped industrial plants adopted these technological advancements to deliver promising healthcare products. These processes ensure the removal of contaminants and enhance the quality, purity, and concentration of desired products. The noticeable companies such as Biocon Biologics, Lupin Limited, Pfizer, GlaxoSmithKline, etc. address global medical needs and provide generics, biosimilars, branded formulations, and novel biologics. These purified materials can be used to invent novel therapies to cure patients suffering from diabetes, immune dysfunction, cancer, and other health disorders.
Role of Artificial Intelligence in the Downstream Processing
The insertion of artificial intelligence in downstream processing revolutionized industrial performance by optimizing production efficiency. AI-driven bioreactors are adjustable to changing conditions and can improve the maximum product yield by reducing operation costs. Artificial intelligence and machine learning technologies enable the identification of equipment failures, optimization of process parameters, and enhancement in process control. Manual errors in traditional methodologies are replaced with industrial automation and modernized technologies. The remote monitoring of various production cycles or ongoing series of events is possible with the help of AI-assisted tools.
Major Trends in the Downstream Processing Market
• Research and Development in Biopharmaceuticals: The clinical development programs in biopharma companies shifted towards research in oncology, immunology, and COVID-19 pandemics to invent advanced therapies. About 69 novel active substances (NAS) were launched globally in 2023 and the use of predictive biomarkers, novel trial design, and digital trial methods enhanced the clinical development productivity.
• Novel Medicinal Treatments: The supportive care and diagnostics play important roles in healthcare. The rise in infectious diseases led to the need for anti-parasitic, anti-bacterial, and anti-fungal treatments including HIV, smallpox, Ebola, etc. The analytical skills of expertise, data analytics, and technology-driven innovations are groundbreaking.
• Sustainability in Downstream processing: The industrial performance parameters are set to achieve maximum production yield and recovery of products by reducing costs of production and minimizing harmful effects on the environment. The sustainable industrial practices are preferred through the conservation of resources, minimization of water and energy consumption, reduction of waste generation, and production of environmentally friendly materials. Several industries have adopted the use of biodegradable chromatography resins and energy-efficient filtration systems.
Why is downstream processing important?
Downstream processing is a critical aspect
of biotechnology because it enables the separation, purification and recovery
of a target product from a complex mixture of biological materials. The target
product can be a protein, nucleic acid, virus or cell used in various
applications, including biopharmaceuticals, industrial enzymes and vaccines.
Downstream processing involves a series of
complex steps that can be time-consuming and costly. The purification of a
target product often requires multiple steps of chromatography, filtration and
centrifugation, which can take several days to complete. Additionally, the
equipment and materials needed for downstream processing can be expensive and
require specialized knowledge and skills.
Another significant pain point in downstream processing is the potential for
product degradation. The target product can be easily denatured, aggregated or
degraded by environmental factors such as pH, temperature and shear forces. It
can lead to the loss of product yield and quality loss, significantly impacting
the final product’s safety and efficacy.
Despite these challenges, downstream processing is essential for producing safe
and effective biopharmaceuticals. The purity and quality of the final product
are critical for regulatory approval and patient safety. Technological
advancements, such as high-throughput screening and automated purification
systems, have recently improved the downstream processing’s efficiency and
speed, making it more accessible and cost-effective for the biotech industry.
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U.S. Downstream Processing Market Size Report, 2033
The U.S. downstream processing market size was exhibited at USD 7.95 billion in 2024 and is projected to hit around USD 27.20 billion by 2033, growing at a CAGR of 20.37% during the forecast period 2024 to 2033.
North America dominated the downstream processing market in 2023 due to supportive government initiatives and expanding biopharmaceutical industries. The U.S. Department of Energy (DOE) aims to conduct projects to deliver a durable and secure battery manufacturing supply chain for the American people. This initiative is supported by the Office of Manufacturing and Energy Supply Chains. For this purpose, the U.S. DOE planned to invest $16 billion in battery manufacturing, processing, and recycling. This supportive governmental measure will also create 6,000 operating jobs and 13,000 construction jobs all across the nation. In September 2024, the U.S. DOE invested $3 billion in 25 projects across 14 states to boost the production of advanced batteries and battery materials nationwide. Moreover, the U.S. Energy Information Administration is the statistical and analytical agency that collects and analyses energy information to promote policymaking and public understanding of energy. It provides statistical data about the supply, refining, and processing of crude oil, gasoline, diesel, ethanol, etc.
• In November 2024, Novartis announced an upgrade to its mid-term guidance, focusing on core therapeutic areas to achieve long-term progress.
• In July 2024, Evotec announced a partnership with Pfizer to focus on research and development for potential therapeutics to treat infectious and metabolic diseases.
Asia Pacific is anticipated to be the fastest-growing region in the downstream processing market during the forecast period due to favorable policies and government support to several industries. The government encourages the downstream processing of local and healthcare products through robust partnership programs with small and medium enterprises. The accreditation and certification are provided to industries like food technology, cosmetics processing, and manufacturing for import and export markets. Several other industries like fisheries, agriculture, and forestry sectors are also provided with governmental support for the production of a variety of products like oil, honey, timber, etc.
• In October 2024, the Serum Institute of India Pvt. Ltd. received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) which recommends the approval of SIILTIBCY® - Mycobacterium tuberculosis derived antigens (rdESAT-6 and rCFP-10) in the European markets.
• In September 2024, Biocon Biologics announced the presentation of new dermatology data at the European Academy of Dermatology and Venereology (EADV) 2024 Congress in Amsterdam which were the results of two separate phase 3 clinical studies.
Downstream Processing Market Report Scope
|
Report Attribute |
Details |
|
Market size value in 2025 |
USD 35.56 billion |
|
Revenue forecast in 2033 |
USD 101.43 billion |
|
Growth rate |
CAGR of 14% from 2023 to 2033 |
|
Base year for estimation |
2024 |
|
Historical data |
2019 - 2023 |
|
Forecast period |
2024 - 2033 |
|
Quantitative units |
Revenue in USD billion and CAGR from 2024 to 2033 |
|
Report coverage |
Revenue forecast, company ranking, competitive landscape, growth factors, and trends |
|
Segments covered |
Product, technique, application, region |
|
Regional scope |
North America; Europe; Asia Pacific; Latin America; MEA |
|
Country scope |
U.S.; Canada; Germany; UK; France; Italy; Spain; Denmark; Sweden; Norway; China; Japan; India; South Korea; Australia; Thailand; Brazil; Mexico, Argentina; South Africa; Saudi Arabia, UAE; Kuwait |
|
Key companies profiled |
Merck KGaA; Sartorius Stedim Biotech S.A; GE Healthcare; Thermo Fisher Scientific Inc.; Danaher Corporation; Repligen; 3M Company; Boehringer Ingelheim International GmbH; Corning Corporation; Lonza Group Ltd; Dover Corporation; Ashai Kasei; Ferner PLC; Eppendorf AG |
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Downstream Processing Market Segmentation Analysis
Product Insights
By product, the chromatography segment emerged as the dominating in the downstream processing market due to its high importance in protein purification. Researchers mainly prefer different chromatography techniques such as ion exchange chromatography, affinity chromatography, etc. to separate and purify biomolecules. The use of high-capacity columns to separate large volumes of proteins with higher flow rates is emerging in research fields. These techniques result in increased productivity and cost-efficiency.
By product, the filter segment is expected to grow at the fastest rate in the downstream processing market over the forecast period due to the applications of ultrafiltration and microfiltration in biopharmaceuticals. These techniques allow the removal of viruses and other contaminants from natural resources with the help of smaller and more efficient filters. A wide use of filters of variable pore sizes and filtration assemblies in research projects and industrial processing boosts the growth of this segment in the market.
Technique Insights
By technique, the purification by chromatography segment dominated the downstream processing market in 2023 due to the essential features and applications of different chromatography techniques and related reaction components. The demand for highly purified proteins, industrial enzymes, and other biomolecules surged the need for adopting chromatography equipment and technical expertise in industrial processing. High-performance liquid chromatography (HPLC), size-exclusion chromatography, thin-layer chromatography, etc. are routinely used biotechniques in bioprocessing operations. The utilization of chromatography resins, columns, reagents, buffers, enzymes, etc. gained high importance in achieving high-throughput results.
By technique, the solid-liquid separation segment is anticipated to be the fastest-growing in the downstream processing market during the forecast period due to the introduction of several methods such as filtration to separate insoluble products including cells, debris, and other particulate matter. In biopharmaceutical manufacturing, it is essential to remove unwanted components like DNA, host cell proteins, and other contaminants from cell culture media to produce desired monoclonal antibodies. These techniques and tools like filtration, depth filters, membrane-sized filters, etc. play important roles in the separation of solid particles from a liquid or gas phase.
Application Insights
By application, the antibiotic production segment dominated the downstream processing market due to the large-scale production and manufacturing of several antibiotics from biopharmaceutical industries. Penicillin, tetracyclin, streptomycin, rifampicin, etc. emerged as the essential components in preventing the growth of microorganisms and reducing disease rates. These antibiotics also play major roles in research experiments by assisting researchers in cell culture media composition and targeting specific results.
By application, the vaccine production segment is anticipated to be the fastest-growing in the downstream processing market during the forecast period due to the global need for life-saving vaccines during pandemics and epidemics. The novel vaccines are manufactured by leading industrial players like Serum Institute of India, Pfizer, etc. to help people fight against severe health diseases. The COVID-19 pandemic surged the demand for advanced therapies, treatments, and vaccines that provide immune protection and improve global health.
Competitive Landscape and Major Breakthroughs in the Downstream Processing Market
The downstream processing market continues to evolve rapidly and showcases remarkable advancements in 2023 and 2024 with a dynamic competitive landscape. Major players such as Serum Institute of India, Pfizer, Biocon Biologics, Lupin Limited, GlaxoSmithKline, Novartis, AstraZeneca, etc. hold a dominating position in the downstream processing market. These companies are setting outstanding benchmarks in scientific innovation, R&D efforts, promising customer care, and impactful product delivery.
What is Going Around the Globe?
• In May 2024, the Serum Institute of India announced a strategic investment in IntegriMedical to accelerate the development and commercialization of India’s first needle-free injection system (N-FIS) technology that will be widely accessible to patients in India and worldwide.
• In August 2024, NC State University and Novartis Gene Therapies partnered to promote the manufacturing of gene and cell therapies by focusing on Lentivirus which is an important gene delivery vector used to treat aggressive cancers.
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Downstream Processing Market Companies
• BoehringerIngelheim
• Danaher Corporation
• Sartorius Stedium Biotech S.A
• GE Healthcare
• Merck Millipore
• Eppendorf AG
• 3M Company
• Thermo Fisher Scientific Inc
• Finesse Solutions Inc
• Lonza Group
Segments Covered in the Report
By Product
• Centrifuges
• Dryers
• Chromatography Systems
• Filters
• Evaporators
• Others
By Application
• Antibodies Production
• Antibiotic Production
• Hormone Production
• Enzyme Production
• Vaccine Production
By Technique
• Purification by Chromatography
• Solid-liquid Separation
o Centrifugation
o Filtration
• Cell Disruption
• Concentration
• Formulation
By Geography
• North America
• Asia Pacific
• Europe
• Latin America
• Middle East and Africa
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