Novo Nordisk to present new cardiometabolic and renal data, including with semaglutide, at Kidney Week 2024, ObesityWeek®, The Liver Meeting®, and AHA Scientific Sessions 2024

• Data unveils new insights into treatment for type 2 diabetes, obesity, cardiovascular, kidney and liver diseases
• Cardiometabolic diseases, including cardiovascular disease, obesity, type 2 diabetes, and MASH, are increasing in prevalence in the U.S. and are associated with high disease burden and increased medical costs^1-4
• Multiple presentations planned at Kidney Week 2024, ObesityWeek^®, The Liver Meeting^®, and American Heart Association (AHA) Scientific Sessions 2024

PLAINSBORO, N.J., Oct. 23, 2024 /PRNewswire/ -- Novo Nordisk today announced that new clinical trial data spanning the company’s research and industry-leading cardiometabolic portfolio, will be presented across four medical congresses, building on the company’s focus on driving change to defeat serious chronic disease and improve patient care.

These upcoming presentations will add to the data about semaglutide’s effects on cardiometabolic conditions and build on previously presented findings.

“Cardiometabolic diseases represent some of the most significant health challenges facing the world today. Our cardiometabolic research is deepening our understanding of the interconnected nature of chronic conditions such as diabetes, obesity, cardiovascular, kidney, and liver diseases,” said Michelle Skinner, PharmD, Vice President, Medical Affairs at Novo Nordisk. “Through research, we aim to further explore treatment options for those most affected, aligning with our commitment to advance scientific frontiers in chronic disease management.”

A significant number of Americans are affected by cardiometabolic diseases, which have been on the rise during the last several decades.¹ T2D and cardiovascular disease (CVD) are highly prevalent,^5,6 and CVD is the leading cause of death in the U.S.⁷ Having either obesity or CKD increases the risk of developing interconnected cardiometabolic disease.^8-10 The obesity epidemic also is contributing to the increasing global prevalence of MASH (metabolic dysfunction-associated steatohepatitis), a serious chronic condition caused by the buildup of extra fat in the liver and characterized by liver inflammation and injury, with or without fibrosis.^11-14 The totality of Novo Nordisk data to be presented at these upcoming congresses will further highlight Novo Nordisk’s commitment to researching serious, chronic diseases.

“Patients with cardiometabolic disease face a host of comorbid conditions. Improving care for them by helping reduce their risk of developing serious, potentially life-threatening complications is at the core of Novo Nordisk’s research and development program, and this will be reflected in our upcoming data presentations,” said Michelle Skinner. “We are excited to share our growing body of data investigating semaglutide and its potential to provide broader benefits to patients living with these common and intractable diseases.”

Select Novo Nordisk abstracts to be presented, these data for semaglutide are investigational:

American Society of Nephrology, Kidney Week 2024, October 23 to 27 [San Diego]

ObesityWeek^® 2024, November 3 to 6 [San Antonio]

The American Association for the Study of Liver Diseases (The Liver Meeting^®) 2024, November 15 to 19 [San Diego]

American Heart Association Scientific Sessions 2024, November 16 to 19 [Chicago]

About Cardiometabolic Diseases

Cardiometabolic diseases encompass some of the most significant health challenges facing the world today. These common conditions, which often overlap and can coexist in the same patient, include CVD and metabolic diseases, such as T2D, obesity, and MASH.^15,16

A significant proportion of the cardiovascular risk associated with these diseases is attributable to shared metabolic risk factors.¹⁶ CVD accounts for around 70% of deaths in people living with obesity and is the leading cause of death in people with T2D, CKD and MASH.^{9,16, 17,18}

About Novo Nordisk

Novo Nordisk is a leading global healthcare company that’s been making innovative medicines to help people with diabetes lead longer, healthier lives for more than 100 years. This heritage has given us experience and capabilities that also enable us to drive change to help people defeat other serious chronic diseases such as obesity, rare blood, and endocrine disorders. We remain steadfast in our conviction that the formula for lasting success is to stay focused, think long-term, and do business in a financially, socially, and environmentally responsible way. With its U.S. headquarters in New Jersey and commercial, production, and research facilities in seven states plus Washington DC, Novo Nordisk employs approximately 8,000 people throughout the country. For more information, visit novonordisk-us.com, Facebook, Instagram, X, LinkedIn, and YouTube.

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References

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2. Jardim TV, Mozaffarian D, Abrahams-Gessel S, et al. Cardiometabolic disease costs associated with suboptimal diet in the United States: A cost analysis based on a microsimulation model. PLoS Med. 2019;16(12):e1002981. Published 2019 Dec 17. doi:10.1371/journal.pmed.1002981.
3. MedlinePlus: Non-alcoholic fatty liver disease. Available at: https://medlineplus.gov/genetics/condition/non-alcoholic-fatty-liver-disease/. Last Accessed October 2024.
4. American Liver Foundation. NASH definition & prevalence. Last updated July 2, 2021. Last accessed: October 2024. Available at: https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/nonalcoholic-steatohepatitis-information-center/nash-definition-prevalence/.
5. Centers for Disease Control and Prevention. Type 2 Diabetes. Last accessed September 2024. Available at: https://www.cdc.gov/diabetes/about/about-type-2-diabetes.html.
6. Roth GA, Mensah GA, Johnson CO, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019. J Am Coll Cardiol. 2020;76(25):2982-3021. doi:10.1016/j.jacc.2020.11.010.
7. Centers for Disease Control and Prevention. Leading Causes of Death. Last accessed: September 2024. Available at: https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm.
8. Valenzuela PL, Carrera-Bastos P, Castillo-García A, et al. Obesity and the risk of cardiometabolic diseases. Nat Rev Cardiol. 2023;20(7):475-494. doi:10.1038/s41569-023-00847-5.
9. Jankowski J, Floege J, Fliser D, Böhm M, Marx N: Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options. Circulation. 2021, 143:1157-72. 10.1161/CIRCULATIONAHA.120.050686.
10. Sanyal AJ, Husain M, Diab C, et al. Cardiovascular disease in patients with metabolic dysfunction-associated steatohepatitis compared with metabolic dysfunction-associated steatotic liver disease and other liver diseases: A systematic review. Am Heart J Plus. 2024;41:100386. Published 2024 Mar 24. doi:10.1016/j.ahjo.2024.100386.
11. Global Liver Institute. The language of NASH. Accessed August 29, 2023. https://globalliver.org/wp-content/uploads/2022/06/GLI_TheLanguageofNASH_270820.pdf.
12. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328-357.
13. Estes C, Razavi H, Loomba R, Younossi Z, Sanyal AJ. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology. 2018;67(1):123-133.
14. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73-84.
15. Marassi M, Fadini GP. The cardio-renal-metabolic connection: a review of the evidence. Cardiovasc Diabetol. 2023 Jul 31;22(1):195. doi: 10.1186/s12933-023-01937-x. PMID: 37525273; PMCID: PMC10391899.
16. Shroff H, VanWagner LB. Cardiovascular Disease in Nonalcoholic Steatohepatitis: Screening and Management. Curr Hepatol Rep. 2020;19(3):315-326. doi:10.1007/s11901-020-00530-0.
17. Khafagy R, Dash S. Obesity and Cardiovascular Disease: The Emerging Role of Inflammation. Front Cardiovasc Med. 2021;8:768119. Published 2021 Oct 25. doi:10.3389/fcvm.2021.768119.
18. Ma, CX., Ma, XN., Guan, CH. et al. Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management. Cardiovasc Diabetol 21, 74 (2022). https://doi.org/10.1186/s12933-022-01516-6.

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