Protein A Resins Market Size, Share, Growth, Trends | Report 2022-2030

The global Protein A resins market size was estimated at around USD 536.67 million in 2021 and it is projected to hit around USD 1.03 billion by 2030, growing at a CAGR of 7.51% from 2022 to 2030.

Protein A resins are the most frequently used resins in affinity chromatography mediums in bio-manufacturing. They are designed to achieve easy, one-step purification of fragments, sub-classes, and classes of immunoglobulins from cell culture media and biological fluids. It can also be used for the immunoprecipitation of antigens, proteins, and protein complexes. Rising focus on drug development by pharmaceutical and biotechnology companies and increasing investments in synthetic biology are expected to accelerate industrial growth. Protein-engineered products are widely used in biopharmaceutical industries in their research activities to develop drugs. Due to the high affinity and selectivity of protein A resins 99% purity can be gained in the utmost generic form.

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Monoclonal antibodies have proven to be efficient, effective, and better tolerated in treating various diseases including cancer. Many strategic initiatives are being taken by several companies to develop monoclonal antibodies to treat COVID-19. For instance, in May 2022, RQ biotechnology received funding of $157 million from a licensing deal with AstraZeneca to focus on the development of early stage monoclonal antibodies against COVID-19 infection. In addition, in May 2022, Roche pharma launched a drug for breast cancer using two monoclonal antibodies Perjeta (pertuzumab) and Herceptin(trastuzumab) which can be administered by single injection and reduces the treatment time by 90%. Since protein A resins are required in the purification of antibodies, increase in monoclonal antibodies to treat various diseases is expected to boost the protein A market growth during the forecast period.

Increasing demand for disposable pre-packed columns owing to their benefits such as operational flexibility with rapid changeovers and quicker set up are increasing their adoption in the manufacturing process. Furthermore, these columns eliminate the work involved in sterilization, packing and cleaning, reduce labor-time including column testing, validation, and documentation, and allow for more runs. The protein A resins are packed in the disposable pre-packed columns, therefore a growing demand for disposable pre-packed columns significantly fuels the protein A market.

Furthermore, the development of novel resins from several players in the market to address the key requirements in the industry is anticipated to drive the market. For instance, in October 2021, Purolite reported the commercialization of two protein A resins Praesto Jetted (dT)18-DVB and Praesto Jetted A50 HipH designed for the purification of antibodies. Similarly, in March 2020, Avantor launched a novel protein a resin PROchievA to improve the downstream purification for monoclonal antibodies production in bioprocessing industry.

The market is segmented by type, product, application, end-user and region. The type segment is based on natural protein A and recombinant protein A. The product segment is based on agarose- based protein A, glass/silica based protein A, and organic polymer based protein A. The application segment is based on antibody purification and immunoprecipitation. The end-user segment is based on pharmaceutical and biopharmaceutical companies, academic research institutes and others.

Scope of The Report

Key Market Trends

Pharmaceutical and Biopharmaceutical Companies are Expected to Dominate the End User Segment

In any drug discovery and development activity carried out in pharma companies, proteins are the principal target, and thus, protein analysis has a very important role in drug discovery and development. The common application of protein analysis involves target identification and evaluation, identification of efficacy and toxicity biomarkers from readily accessible biological fluids, and investigations into mechanisms of drug action or toxicity, among others, which in turn is expected to grow significantly due to a large number of ongoing drug discovery projects initiated by pharmaceutical companies around the world.

Additionally, chromatography is widely used across these companies in which protein A resin is commonly used. A rise in government funding in pharmaceutical research and development, technological advancements in the area of analytical instruments, increasing life science R&D expenditure, progressing drug discovery, and an increase in the adoption of chromatography are the key factors driving the growth of the protein A resins market in the pharmaceutical and biotechnology industry. For instance, in February 2020, Shimadzu Corporation, in partnership with the Enabling Technologies Consortium (ETC), announced the release of the NexeraPreparative Supercritical Fluid Chromatography System, “NexeraUC Prep”. This next-generation prep SFC system provides the pharmaceutical industry with reliable, high-performance semi-prep purification involving protein A resin. Each NexeraUC Prep is configurable to user specifications to perform the desired purification function optimally, including chiral or achiral purifications, single injections, stacked injections, and fraction collections from several microliters to liters. As the above-mentioned chromatography system is associated with protein A resin, the market studied is expected to grow with such developments. 

Hence, the factors such as product launches and strategic initiatives by market players such as rising investments, the launch of new companies, partnerships, and others are expected to contribute significantly to the segment growth.

Key Players

• GE Healthcare
• Merck Millipore
• PerkinElmer
• GenScript Biotech Corporation
• Agilent Technologies
• Repligen Corporation
• Thermo Fisher Scientific
• Bio-Rad Laboratories
• Abcam
• Novasep Holding SAS
• others

Market Segmentation

• By Type
  • Natural Protein A
  • Recombinant Protein A
• By Product
  • Agarose-based Protein A
  • Glass/Silica-based Protein A
  • Organic Polymer-based Protein A
• By Application
  • Antibody Purification
  • Immunoprecipitation
• By End-user
  • Pharmaceutical & Biopharmaceutical Companies
  • Academic Research Institutes
  • Others
• By Region
  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

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