ST. LOUIS, Oct. 2 /PRNewswire-FirstCall/ -- Sigma-Aldrich , a leading $1.7 billion Life Science company and member of The RNAi Consortium (TRC), proudly welcomes the University of Edinburgh to the RNAi Partnership Program. As the newest member of the RNAi Partnership Program, the University of Edinburgh gains access to cutting-edge products in Sigma-Aldrich’s functional genomics portfolio, including TRC shRNA libraries that target more than 15,000 human and another 15,000 mouse genes.
“We are very pleased to be able to expand our working relationship with the University of Edinburgh,” said Henry van Oudenaren, Sigma-Aldrich’s Regional Managing Director for the UK and Ireland. “And we will continue to look for innovative ways that Sigma-Aldrich can accelerate this partner’s success.”
Simon Brown, a Group Leader at the University of Edinburgh/MRC Centre for Inflammation Research (CIR), said: “We are pleased to become a member of the Sigma-Aldrich RNAi Partnership Program and look forward to a productive collaboration. Access to the TRC Mission shRNA Library will greatly accelerate our ability to prioritize genes that are of particular interest to us, which we have identified from various proteomic and genomic screens. In having access to three to five pre-packaged lentiviral particles per target gene for the knock-down of over 15,000 transcripts, excluding alternatively spliced variants, we have a resource that provides significant and ever increasing coverage of both the human and mouse genome. Furthermore, shRNA allows us to bypass chemical siRNA for a more efficient viral transduction approach, both in vitro and in vivo.”
Through the RNAi Partnership Program, Sigma-Aldrich aims to establish collaborations with select academic institutions to advance functional genomics research by aiding academic researchers with early exposure to emerging new techniques, a broad portfolio of intellectual property and special partnership pricing on Sigma-Aldrich’s extensive RNAi product lines. Members of the RNAi Partnership Program enjoy unique access to cutting-edge tools for studying the underlying cause of disease and elucidating basic gene function.
Sigma-Aldrich’s rapidly growing offering includes various products positioned along the functional genomic research workflow, such as the lentivirus-based MISSION(TM) TRC shRNA libraries, activated lentiviral particles, custom siRNA and QPCR reagents.
Sigma-Aldrich has made a major commitment to the rapidly developing area of RNAi. This commitment began with the establishment of a research collaboration with TRC, which consists of a partnership among the Broad Institute, MIT, Harvard, Dana Farber and other research organizations and several major pharmaceutical companies. This was followed by a license with MIT to make and sell the shRNA libraries developed by TRC and, subsequently, the introduction of Sigma-Aldrich’s MISSION(TM) TRC shRNA Libraries. The acquisition of Proligo secured Sigma-Aldrich’s ability to synthesize RNA and provided access to one of only four licenses to a key MIT patent for RNAi. Additional agreements with Alnylam, Benitec and Oxford BioMedica provide Sigma-Aldrich with a major intellectual property portfolio in RNAi.
Existing members of the Sigma RNAi Partnership Program include Rutgers University, University of Medicine & Dentistry New Jersey, The Wistar Institute, Tufts University, Washington University of Saint Louis, Moore’s Cancer Center UCSD, and others.
To find out more about the Program and how to become a member, please visit us online at http://sigma-aldrich.com/rnai .
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 35 countries and has 7,200 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award- winning Web site at sigma-aldrich.com.
About TRC: TRC is comprised of principal investigators from world-class academic research institutions (Massachusetts Institute of Technology, Harvard Medical School, the Broad Institute, Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Massachusetts General Hospital, Washington University, Columbia University, and Academia Sinica) as well as corporate sponsoring institutions (Sigma-Aldrich, Novartis, Eli Lilly, and Bristol-Myers Squibb).
The MISSION TRC shRNA clone libraries will comprise a comprehensive collection of 150,000 pre-cloned lentiviral-based shRNA vector constructs targeting 15,000 human genes (MISSION TRC-Hs1.0) and 15,000 mouse genes (MISSION TRC-Mm1.0). Design and development of the TRC libraries is being led by the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard. For more information about MISSION shRNA clone collections, please visit us online at http://sigma-aldrich.com/rnai .
Cautionary Statement: This release contains forward-looking statements relating to future performance, goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding the Company’s expectations, goals, beliefs, intentions and the like, which involve assumptions regarding the Company’s operations and conditions in the markets the Company serves. The Company does not undertake any obligation to update these forward-looking statements.
Photo: http://www.newscom.com/cgi-bin/prnh/20050215/CGSIGMAALLOGOAP Archive: http://photoarchive.ap.orgPRN Photo Desk, photodesk@prnewswire.comSigma-Aldrich
CONTACT: Sean Battles of Sigma-Aldrich, +1-314-286-7616,sean.battles@sial.com
