Publication in peer-reviewed journal Science demonstrates the foundation of the company’s evolution-based, data-driven engineering technology to build artificial functional enzymes
| CHICAGO, July 23, 2020 /PRNewswire/ -- A publication released in the peer-review journal Science today demonstrates the foundation of Evozyne’s evolution-based, data-driven engineering process for building artificial functional enzymes. Founded by life science innovator Paragon Biosciences, Evozyne, a privately held molecular engineering technology company, is focused on creating novel proteins to facilitate innovation and growth across multiple industries. “This publication demonstrates that mining genomic data guided by machine learning, which is the underlying approach of Evozyne, can lead to powerful design models that can rapidly generate effective solutions for key societal challenges,” said Rama Ranganathan, M.D., Ph.D., co-founder and chief scientific officer of Evozyne, and primary author of the paper. “We were able to focus the design model towards function in a specific genomic context and show that sequence-based statistical models are sufficient to specify proteins and provide access to an enormous space of new, unexplored functional sequences. This is a major advance in life science and materials research that has the potential to enable innovation and growth across all aspects of human life.” The Science paper - “An evolution-based model for designing chorismate mutase enzymes” - describes a process to identify nature’s design rules for specifying proteins purely from evolutionary sequence data and apply those rules using new advanced engineering technologies to build libraries of synthetic molecules. Using this approach, Dr. Ranganathan and his team then tested the designed molecules for activity in vivo, in their natural biological context. For chorismate mutase, a key enzyme in the biosynthesis of aromatic amino acids, the results demonstrated natural-like enzyme function with substantial sequence diversity. Applying this technology, Evozyne can create novel proteins to address fundamental challenges, such as climate change and clean energy, by:
“Through its novel application of synthetic biology, Evozyne is addressing human and societal challenges in ways that were previously unimaginable,” said Jeff Aronin, founder, chairman and chief executive officer of Paragon Biosciences. “At Paragon, we create and support focused visionary companies, like Evozyne, to accelerate life science innovations.” Evozyne, a Chicago-based company, has assembled a strong technical team, attracting remarkable talent from life science hubs throughout the country. The company looks to expand soon to continue its important work. About Data-Driven Molecular Engineering Technology Evozyne is creating novel proteins with exceptionally advanced functionality. Through computational modeling, gene synthesis and high-throughput assays, Evozyne learns from evolution and rationally searches a vast design space to generate a pipeline of synthetic proteins with desired functionality. These proteins are developed specifically to meet a need, with applications across a variety of industries including agricultural, biopharmaceutical, industrial, energy, and environmental. Synthetic proteins developed with Evozyne’s technology could be used to:
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